Is NCT06229834 recruiting in Boston, MA?

Yes, NCT06229834 is currently recruiting participants at its Boston, MA location. This episodic migraine clinical trial is actively enrolling qualified participants.

How do I join the episodic migraine clinical trial in Boston?

To join this clinical trial in Boston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Boston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Episodic Migraine Clinical Trial in Boston, MA

About This Episodic Migraine Study in Boston

Migraine, a chronic intermittent headache disorder, ranks in the top five causes of years lived with disability. One promising non-pharmacologic and integrative treatment for migraine may be chiropractic care due to the co-occurrence of migraine and musculoskeletal complaints. The goal of this application is to perform a pilot study of chiropractic care for episodic migraine to help inform the design of a future, full-scale pragmatic effectiveness trial.

Sponsor: Brigham and Women's Hospital

Who Can Participate

Inclusion Criteria

Age 18-65 years

Confirmed diagnosis of migraine with or without aura which does not meet criteria for chronic migraine according to the International Classification for -Headache Disorders (ICHD)-3 guidelines at the screening visit with the study physician

History of migraines dating for at least one year

Completion of at least 26 headache diary days out of 28

Confirmed migraine frequency ≥4 to ≤13 days per month during a run-in period

If use of medication is applicable, dose must be stable for 2 months prior to study enrollment

If use of medication for non-migraine pain condition is applicable (with the exception of episodic tension type headache), dose must be stable for 2 months prior to study enrollment

Willing and able to complete all study procedures and be randomized to either of the two intervention groups

Fluency in English

Confirmed access to and proficiency with use of a smartphone, computer, and/or tablet

Working email address or willingness to create an email account for the study

Exclusion Criteria

Non-Veterans (VAMC only)

Received botulinum toxin treatment for headache and/or neck pain within the 4 months prior to the start of the baseline phase

Received chiropractic care for any condition within the 3 months prior to the start of the baseline phase

Received behavioral interventions (e.g., cognitive behavioral therapy, acceptance and commitment therapy, mindfulness, relaxation techniques, hypnosis) within the past 3 months)

Used neuromodulation (i.e., "headache devices"), procedures for migraine prevention within the 2 months before the baseline period, or investigational medications or headache devices for at least 90 days prior to screening

Diagnosis of medication overuse headache according to the ICHD-3 guidelines at the screening visit with the study physician

Traumatic Brain Injury ≤ 1 year before screening visit or worsening of migraine as noted by the screening study physician

Head or neck trauma within the past year causing neurological or musculoskeletal signs or symptoms requiring treatment

Any medical, neurologic, or psychiatric condition that the screening study physician deems would lead to difficulty complying with the protocol or negatively impact the safety profile of the interventions

Psychiatric hospitalization in the last 6 months

Receiving hospice or palliative care

History of carotid or vertebral artery dissection

Presence of carotid bruits

Presence of contraindications (relative or absolute) for spinal manipulation or mobilization where these procedures cannot be modified for safe administration and are consistent with those published by the World Health Organization (WHO) guidelines, including but not limited to:

Local spinal hypermobility/instability

Conditions causing general spinal hypermobility, such as Marfan, Ehlers-Danlos syndrome, and Osteogenesis imperfecta

Malignancy of the spine or spinal cord

Frank disc herniation with signs of progressive neurological deficit

Spinal or intracanalicular hematomas Inflammatory spondyloarthropathies such as rheumatoid arthritis

Spinal fractures or dislocations

Avascular necrosis in an area of proposed joint manipulation

Bone-weakening disorders affecting the spine, such as benign bone tumors, infection, or osteoporosis

Vertebrobasilar insufficiency syndrome

Aneurysm involving a major blood vessel in an area of potential joint manipulation

History of stroke

Anticoagulant therapy or blood disorders cause significant bleeding tendency

Cervical spine congenital anomalies that affect the stability or neurologic integrity of the individual or history of cervical spine surgery

Either self-reported current alcohol or substance use disorder or current alcohol or substance use disorder documented by a treating medical provider within the past 6 months

Hormone replacement therapy for less than six months, or if prescriptions greater than 6 months in duration must be at a stable dose

Significant cognitive impairment that would impair participation in the trial

Currently pregnant or intention to become pregnant within the next six months

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT06229834) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Episodic Migraine Treatment Options in Boston, MA

If you're searching for episodic migraine treatment options in Boston, MA, this clinical trial (NCT06229834) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced episodic migraine specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all episodic migraine clinical trials near you to find additional studies recruiting in your area.

Episodic Migraine Clinical Trial in Boston, MA

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