Durham, NCNCT07603375Now EnrollingIRB Ready

Esophageal Adenocarcinoma Clinical Trial in Durham, NC

Access cutting-edge esophageal adenocarcinoma treatment through this phase 2 clinical trial at a research site in Durham. Study-provided care at no cost to qualified participants.

Sponsored by Duke University

Quick Self-Assessment

See if you qualify for this Durham location

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Expert Care in Durham

Access esophageal adenocarcinoma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related esophageal adenocarcinoma treatment provided free

Apply for This Durham Location

Check if you qualify for this esophageal adenocarcinoma clinical trial in Durham, NC

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Durham

    Convenient for NC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Durham site if eligible
  4. 4Begin participation

About This Esophageal Adenocarcinoma Study in Durham

The goal of this trial is to learn if adding consolidative chemotherapy to routine chemoradiation can better control both local recurrence and metastasis and reduce the need for surgical intervention.

Sponsor: Duke University

Who Can Participate

Inclusion Criteria

Subject must be able to provide study specific informed consent prior to study entry
Must be newly diagnosed, histologically proven diagnosis of adenocarcinoma of the thoracic esophagus or gastroesophageal junction (Siewert I-II);
Stage II-IVA, excluding T4b, according to the American Joint Committee on Cancer (AJCC) 8th edition;
Complete history and physical examination within 21 days of signing consent;
Staging whole-body FDG-PET/CT (fluorodeoxyglucose-positron emission tomography/computed tomography) scan with or without contrast (preferred) or chest/abdominal (CT with contrast) confirming there is no evidence of metastatic disease must be obtained within 45 days of study enrollment
ECOG (Eastern Cooperative Oncology Group) performance status of 0-2
Subjects must be appropriate candidates for planned chemoradiation (concurrent carboplatin/paclitaxel) and chemotherapy (FLOT, m-FOLFOX-6) as determined by the treating radiation oncologist, medical oncologist, and surgical oncologist.
Adequate hematologic, renal, and hepatic function within 14 days of initiation of therapy

Exclusion Criteria

Cervical esophageal cancers arising 15-18 cm from the incisors.
Esophageal squamous cell carcinoma.
Patients with T4b disease according to the AJCC 8th Edition.
Definitive clinical or radiologic evidence of metastatic disease.
Has had prior systemic therapy or radiation therapy for the current diagnosis.
Prior thoracic radiotherapy for any reason that would result in overlap of radiation therapy fields; all patients with prior radiotherapy must be reviewed by the PI to determine if patient is eligible.
Has a known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer
Severe, active co-morbidity defined as follows:
Active uncontrolled infection requiring IV antibiotics;
Pregnant and/or nursing subjects;
HIV positive with CD4 count \< 200 cells/microliter. Note that subjects who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count ≥ 200 cells/microliter within 30 days prior to registration. Note also that HIV testing is not required for eligibility for this protocol. This exclusion criterion is necessary because the treatments involved in this protocol may be significantly immunosuppressive.
Has a history or current evidence of physical or physiological contraindication to participation in this study, at the discretion of the treating investigator.
Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Durham?

Yes, this clinical trial (NCT07603375) has an active research site in Durham, NC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Esophageal Adenocarcinoma Treatment Options in Durham, NC

If you're searching for esophageal adenocarcinoma treatment options in Durham, NC, this clinical trial (NCT07603375) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Durham research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced esophageal adenocarcinoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all esophageal adenocarcinoma clinical trials near you to find additional studies recruiting in your area.

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