Philadelphia, PANCT06413355Now EnrollingIRB Ready

Fibrosis (Morphologic Abnormality) Clinical Trial in Philadelphia, PA

Access cutting-edge fibrosis (morphologic abnormality) treatment through this clinical trial at a research site in Philadelphia. Study-provided care at no cost to qualified participants.

Sponsored by Abramson Cancer Center at Penn Medicine

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Expert Care in Philadelphia

Access fibrosis (morphologic abnormality) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related fibrosis (morphologic abnormality) treatment provided free

Apply for This Philadelphia Location

Check if you qualify for this fibrosis (morphologic abnormality) clinical trial in Philadelphia, PA

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Why Participate?

  • No-Cost Study Care

  • Local to Philadelphia

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Philadelphia site if eligible
  4. 4Begin participation

About This Fibrosis (Morphologic Abnormality) Study in Philadelphia

This protocol is intended as a basket protocol designed to evaluate the use of Fibroblast Activating Protein (FAP) PET/CT in imaging the presence of fibrosis caused by a variety of medical conditions where fibrosis is believed to lead to pathological effects and poor prognosis.

Sponsor: Abramson Cancer Center at Penn Medicine

Who Can Participate

Inclusion Criteria

(by cohort) Head and Neck Cancer Cohort:
Participants will be ≥ 21 years of age
Diagnosis of oropharyngeal squamous cell carcinoma (OPSCC)
Determined to be surgical candidates
History of known or suspected fibrosis-inducing medical condition PTLD Cohort:
Participants will be ≥ 21 years of age
Diagnosed with microbiologically confirmed DS-pTB (culture or PCR positive)
History of known or suspected fibrosis-inducing medical condition.
Patient-reported completion of TB treatment within 2 years of enrollment. Cardiac Sarcoidosis Cohort:
Participants will be ≥ 21 years of age
FDG PET/CT scan consistent with metabolically active cardiac sarcoidosis
Clinical suspicion of cardiac involvement defined as the presence of any of the following:
High degree A-V nodal block
Reduced left or right ventricular systolic fusion
History of ventricular arrhythmias
Unexplained syncope Exploratory Cohort:
Participants will be ≥ 21 years of age
History of known or suspected fibrosis-inducing medical condition. All Cohorts: 1\. Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures.

Exclusion Criteria

(by cohort) Head and Neck Cancer Cohort: 1\. Patient is not eligible for tissue resection PTLD Cohort:
Diagnosed with TB that is resistant to rifampin per medical record review
History of alternative pulmonary disease per medical record review or patient self-report
Have been administered corticosteroids or any other systemic investigational agents within 3 months of screening per medical record review or patient self-report
Have symptoms or signs suggestive of active TB at the time of pre-screening per patient self-report All Cohorts:
Women of childbearing potential may not be pregnant or breast-feeding. A negative pregnancy test will be required before \[F-18\]-FAPI-74injection.
Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study
Treatment with a therapeutic agent targeting fibroblast activation protein (FAP) within 1 month prior to study enrollment.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT06413355) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Fibrosis (Morphologic Abnormality) Treatment Options in Philadelphia, PA

If you're searching for fibrosis (morphologic abnormality) treatment options in Philadelphia, PA, this clinical trial (NCT06413355) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this clinical trial. You'll receive care from experienced fibrosis (morphologic abnormality) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all fibrosis (morphologic abnormality) clinical trials near you to find additional studies recruiting in your area.

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