Santa Monica, CANCT07529808Now EnrollingIRB Ready

Gastric Cancer Clinical Trial in Santa Monica, CA

Access cutting-edge gastric cancer treatment through this phase 1/2 clinical trial at a research site in Santa Monica. Study-provided care at no cost to qualified participants.

Sponsored by BigHat Biosciences, Inc.

Quick Self-Assessment

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Expert Care in Santa Monica

Access gastric cancer specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related gastric cancer treatment provided free

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Check if you qualify for this gastric cancer clinical trial in Santa Monica, CA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Santa Monica

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Santa Monica site if eligible
  4. 4Begin participation

About This Gastric Cancer Study in Santa Monica

This study is looking at how safe BHB810 is in adults with gastric and gastroesophageal adenocarcinoma (GEJ). The purpose of this study is also to look at: how well the study drug works, how the study drug moves into, through, and out of the body, and how your body reacts to the study drug. Participants will get an IV infusion of BHB810 every 2 weeks while on study treatment.

Sponsor: BigHat Biosciences, Inc.

Who Can Participate

Inclusion Criteria

Participant must be ≥ 18 years or the legal age of consent in the jurisdiction in which the study is taking place at the time of signing the ICF.
Histologically confirmed advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma that has progressed on, was nonresponsive to, or for which no standard or available curative therapy exists.
Participants in Phase 1 Backfill Cohorts \& Phase 2 must be CDH17-positive by central testing.
Other gastrointestinal (GI) tumor types may be enrolled in Backfill Cohorts and Phase 2.
At least 1 measurable target lesion at baseline per RECIST 1.1 (Response Evaluation Criteria in Solid Tumors)
Provision of FFPE archival tumor tissue. Additional fresh biopsies at screening are required in Phase 1 Backfill Cohorts and Phase 2.
Adequate organ and marrow function as defined in the protocol

Exclusion Criteria

Prior cancer treatment as follows, relative to the first planned dose of trial intervention:
Chemotherapy or targeted therapy withing 4 weeks or 5-halflives (whichever is shorter)
Monoclonal antibody-based therapy (including ADCs) within 4 weeks
Immune checkpoint inhibitors within 4 weeks
Wide-field radiation therapy (\>30% marrow-bearing bones) within 4 weeks or \< 2 weeks of focal palliative radiation to nontarget lesions
Prior treatment with a CDH17-directed therapy or an ADC with an auristatin (MMAE or MMAF)
Known hypersensitivity or allergic reaction to BHB810 or it's excipients
Left ventricular ejection fraction \<50% or history of congestive heart failure Class III/IV
QTc interval \> 470 msec, history of risk factors for Torsade de Pointes, or taking a medication known to prolong QT/QTc
Pregnant or breastfeeding females, or if you or your partner are planning to become pregnant
Known or suspected brain metastases, leptomeningeal disease, or spinal cord compression. Participants with stable, treated brain metastases may be enrolled.
Current treatment with a strong CYP3A4 inhibitor or inducer, Pgp inhibitor, or CYP3A4 sensitive substrate within 2 weeks of first dose of trial intervention
Any condition that may compromise participant safety, compliance, or interfere with the evaluation of the study drug.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Santa Monica?

Yes, this clinical trial (NCT07529808) has an active research site in Santa Monica, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Gastric Cancer Treatment Options in Santa Monica, CA

If you're searching for gastric cancer treatment options in Santa Monica, CA, this clinical trial (NCT07529808) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Santa Monica research site is actively enrolling participants for this phase 1/2 clinical trial. You'll receive care from experienced gastric cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all gastric cancer clinical trials near you to find additional studies recruiting in your area.

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