NCT07243015 · City of Hope Medical Center
Detection of Minimal Residual Disease Using Exosomal miRNA Distant Metastasis Markers
(DESTINEX-REM)
What this study is about
Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Even in patients undergoing curative surgery for non-metastatic disease, postoperative recurrence frequently occurs due to undetected minimal residual disease (MRD).
View original scientific description
Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Even in patients undergoing curative surgery for non-metastatic disease, postoperative recurrence frequently occurs due to undetected minimal residual disease (MRD). This study aims to establish a highly sensitive and specific liquid biopsy assay using exosomal microRNAs (exo-miRNAs) to detect MRD and predict distant metastasis before clinical recurrence.
Interventions
DIAGNOSTIC_TEST
small RNA-seq or array
small RNA-seq or array
DIAGNOSTIC_TEST
ENLIGHT Assay
RT-qPCR-based exo-miRNA quantification
Primary outcome measures
Recurrence-Free Survival (RFS)
Time frame: up to 5 years
Time from surgery to recurrence or death.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Histologically confirmed gastric adenocarcinoma.
- Underwent curative-intent resection (R0).
- Availability of pre- and postoperative plasma samples.
- Documented clinical follow-up data (recurrence/metastasis status).
- Provided written informed consent.
Exclusion criteria
- Insufficient plasma volume or RNA quality for exosomal extraction.
- Presence of synchronous or metachronous malignancies.
- Received neoadjuvant chemotherapy without postoperative follow-up.
- Lack of consent or incomplete clinicopathologic data.
Where
- Duarte, California
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 6, 2026 · Source of record for eligibility and locations