Stony Brook, NYNCT05423210Now EnrollingIRB Ready

Glioblastoma Multiforme Clinical Trial in Stony Brook, NY

Access cutting-edge glioblastoma multiforme treatment through this early phase 1 clinical trial at a research site in Stony Brook. Study-provided care at no cost to qualified participants.

Sponsored by Stony Brook University

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Expert Care in Stony Brook

Access glioblastoma multiforme specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related glioblastoma multiforme treatment provided free

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Check if you qualify for this glioblastoma multiforme clinical trial in Stony Brook, NY

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Stony Brook

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Stony Brook site if eligible
  4. 4Begin participation

About This Glioblastoma Multiforme Study in Stony Brook

This is a single-arm pilot study that will recruit 12 patients with newly diagnosed Glioblastoma, a malignant brain tumor with a poor prognosis. Patients will be treated with fractionated stereotactic radiotherapy (FSRT) for 2 weeks, in addition to two doses of Atezolizumab (Tecentriq), an FDA approved PD- L1 inhibitor drug, 840 mg IV, at the beginning and at the end of the two-week time period, concomitantly with FSRT. After this initial two weeks treatment the patients will undergo craniotomy and maximal safe resection as per normal care for a GB. After surgery patients will follow the normal care for glioblastoma in addition to Atezolizumab 840 mg IV q2 weeks for the duration of adjuvant treatment.

Sponsor: Stony Brook University

Who Can Participate

Inclusion Criteria

Diagnosis of glioblastoma multiforme WHO Grade IV
The patient is a surgical candidate, with the surgical intent for a \> 80% resection of the lesion
Negative pregnancy test
ECOG status \<= 2
Tumor volume \<= 3.5 cm
Adequate organ function
Negative for infectious disease (human immunodeficiency virus, Hepatitis B Virus, Hepatitis C Virus, tubercolosis)

Exclusion Criteria

Patient already underwent surgical total or partial tumor resection, or radiation therapy
Presence of leptomeningeal disease, gliomatosis cerebri, multifocal disease, bilateral cerebral hemisphere involvement ("butterfly" gliomas)
Patients at increased risk of neurologic decompensation
Continued use of high dose intravenous or oral corticosteroids, or \> 8milligrams per day of systemic dexamethasone
Uncontrolled tumor-related pain
Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently)
Uncontrolled or symptomatic hypercalcemia
History of autoimmune disease or immune deficiency
History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis
Significant cardiovascular disease
History of other malignancy within 1 year prior to screening
Severe infection within 4 weeks prior to initiation of study treatment
History of allogeneic stem cell or organ transplant
Prior treatment with CD137 agonists or immune checkpoint blockade therapies
Treatment with systemic immunostimulatory agents
Treatment with systemic immunosuppressive medication

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Stony Brook?

Yes, this clinical trial (NCT05423210) has an active research site in Stony Brook, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Glioblastoma Multiforme Treatment Options in Stony Brook, NY

If you're searching for glioblastoma multiforme treatment options in Stony Brook, NY, this clinical trial (NCT05423210) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Stony Brook research site is actively enrolling participants for this early phase 1 clinical trial. You'll receive care from experienced glioblastoma multiforme specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all glioblastoma multiforme clinical trials near you to find additional studies recruiting in your area.

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