Cleveland, OHNCT06649201Now EnrollingIRB Ready

Graft Vs Host Disease Clinical Trial in Cleveland, OH

Access cutting-edge graft vs host disease treatment through this clinical trial at a research site in Cleveland. Study-provided care at no cost to qualified participants.

Sponsored by Case Comprehensive Cancer Center

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Expert Care in Cleveland

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related graft vs host disease treatment provided free

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Check if you qualify for this graft vs host disease clinical trial in Cleveland, OH

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Cleveland

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Cleveland site if eligible
  4. 4Begin participation

About This Graft Vs Host Disease Study in Cleveland

The goal of this observational study is to investigate the development of vulvovaginal graft-versus-host- disease (GVHD), an under-reported and under-recognized manifestation of chronic GVHD. This study aims to characterize the vaginal microbiome in participants undergoing allogeneic hematopoietic cell transplantation (HCT). The main questions it aims to answer are: * Is the vaginal microbiome altered during allogeneic HCT? * What changes may help researchers understand the development of vulvovaginal GVHD? Participants will be asked to undergo an assessment of vulvovaginal symptoms through a vulvovaginal symptom questionnaire once pre-transplant, 6 months post-transplant, and twelve12 months post- transplant. Participants will also be asked to undergo a vaginal microbiome (collection of bacteria, fungi, and viruses that live on our bodies) evaluation through a vaginal exam performed by a gynecologist with collection of vaginal samples once pre-transplant and again six months post-treatment and twelve months post-transplant. If a participant develops symptoms of vulvovaginal GVHD at any point in time during the post-transplant follow up, the participant may partake in additional vaginal exams to diagnose GVHD at the time of symptom onset.

Sponsor: Case Comprehensive Cancer Center

Who Can Participate

Inclusion Criteria

Female participants planning to undergo allogeneic HCT for any disease indication, OR, female participants who have already received HCT and have developed vulvovaginal GVHD during their post-transplant follow-up period
All conditioning regimens (myeloablative or reduced intensity) will be included.
All donor sources (HLA matched/mismatched related, unrelated, umbilical cord, haploidentical) will be included.
All graft sources (bone marrow or peripheral blood stem cells) will be included.
All GVHD prophylaxis regimens will be included.
Aged 18-70.
English speaking and able to sign written informed consent.
Participants agree to a vaginal gynecologic exam.
Co-enrollment on other clinical trials will be allowed.

Exclusion Criteria

Participants who decline or unable to undergo vaginal gynecologic exam due to any discomfort or pain.
Any concurrent medical, psychiatric or other illness in which the provider believes the participants may not be able to comply with study assessments.
Participants with a current diagnosis of a sexually transmitted infection (STI) (Herpes Simplex Virus, Gonorrhea, Chlamydia, Trichomonas,) or a history of previously untreated STI which may incite inflammation that will impact the microbiome.
Participants with a history of lichen sclerosis, lichen planus, pre-transplant.
Participants with a history or current diagnosis of vaginal or vulvar malignancy.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cleveland?

Yes, this clinical trial (NCT06649201) has an active research site in Cleveland, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Graft Vs Host Disease Treatment Options in Cleveland, OH

If you're searching for graft vs host disease treatment options in Cleveland, OH, this clinical trial (NCT06649201) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cleveland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced graft vs host disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all graft vs host disease clinical trials near you to find additional studies recruiting in your area.

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