Is NCT07325513 recruiting in San Diego, CA?

Yes, NCT07325513 is currently recruiting participants at its San Diego, CA location. This gulf war illness clinical trial is actively enrolling qualified participants.

How do I join the gulf war illness clinical trial in San Diego?

To join this clinical trial in San Diego, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this San Diego clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Gulf War Illness Clinical Trial in San Diego, CA

About This Gulf War Illness Study in San Diego

The goal of this clinical trial is to create a machine learning algorithm to improve active repetitive transcranial magnetic stimulation (rTMS) treatments for veterans and/or active military personnel by alleviating Gulf War Illness related headaches and body pain (GWI-HAP). This study aims to develop and validate a Support Vector Machine (SVM) model that could replace the trial-and-error process by assessing functional connectivity provided by resting state functional magnetic resonance imaging (rs-fMRI) data to predict the most effective rTMS protocol for each person. All participants will be receiving active rTMS treatment. The main questions it intends to answer are: 1. Does the SVM model predict a more effective treatment response rate for predicted respondents undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) compared to predicted non-respondents? 2. Does the SVM model predict a more effective treatment response rate while undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) and left motor cortex (LMC) in predicted respondents compared to predicted non-respondents? Participants will undergo the following: 1. Receive a total of 13 active rTMS treatment sessions over 3-4 months. 2. Visit the clinic for a total of 15 visits for assessments, check ups, and treatments. 3. Keep a daily log of their headaches, muscle and joint pain throughout the study.

Sponsor: Veterans Medical Research Foundation

Who Can Participate

Inclusion Criteria

Male or female

Veteran or active military personnel

Between the ages of 18 and 65 years old

Served in the Persian Gulf region for at least 30 consecutive days between August 1, 1990, and July 31, 1991

Meets the CDC Criteria for GWVI (GWI), with symptoms starting during or after the 1990-1991 Persian Gulf deployment. Symptoms must be present for at least 6 months prior to enrollment in the study. Symptoms must be present in at least 2 of the 3 categories of fatigue, musculoskeletal, and mood cognitive.

Meets the Kansas Criteria for GWVI (GWI), with symptoms starting during or after the 1990-1991 Persian Gulf deployment. Symptoms must be present for at least 6 months prior to enrollment in the study. Qualifying symptoms must be at least moderate in severity and/or multiple symptoms must be present within at least 3 of 6 categories consisting of fatigue/sleep, neurological/cognitive/mood, pain, respiratory, gastroenterological, and dermatological symptomology.

Average Overall Daily Muscle Pain Intensity ≥3 on a 0-10 NPRS, present for at least 6 months

Average Overall Daily Extremities Joint Pain Intensity ≥3 on a 0-10 NPRS, present for at least 6 months

Average Headache Exacerbation Intensity ≥3 on a 0-10 NPRS, with headaches occurring for at least 6 months

Headache Exacerbation/attack ≥ 1 time per week with the average intensity ≥3 on a 0-10 NPS, lasting \> 1 hour in the past three months

International Headache Society Criteria for Migraine Headache without aura

Exclusion Criteria

Children under the age of 18

Pregnant women

Individuals with cognitive/decisional impairment

Non-English speaking individuals

Prisoners of War

Incarcerated individuals

VA employees - including VA paid, IPA, or WOC

Students of the institution or of the investigator

Patients with cancer

History of pacemaker implant

Presence of ferromagnetic material (e.g., bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI

History of dementia, major psychiatric diseases, or life-threatening diseases

Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy

Known diagnosis of moderate to severe osteoarthritis and/or rheumatologic joint pain prior to the GWI deployment

Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy

Concurrent conditions, like lupus, that can produce symptoms compatible with GWVI

History of seizure

Pending litigation

History of Traumatic Brain Injury-related headaches

Chronic Tension or Cluster Headache. However, subjects with occasional tension headaches (less than once every three months and lasting no more than 24 hours) will not be excluded from the study.

Ongoing Cognitive Rehabilitation or Treatment of PTSD

Recent exacerbation of anxiety disorder symptoms, active substance dependence, and/or current psychotic symptoms

Ongoing suicidal/homicidal ideation or recent (in the past 6 months) suicidal attempts

Patients who receive any narcotic-based analgesic, topical analgesics over the affected site, steroid and local anesthetic injection, anticonvulsants, and antipsychotic medications less than 7 days prior to the pretreatment assessment

Patients who do not agree to avoid use of non-pharmacologic treatments, including but not limited to, transcutaneous electrical nerve stimulation unit (TENS), acupuncture, acupressure, and therapeutic massage during the entire study.

Patients who do not agree to use additional acetaminophen (up to a maximum total of 3g per day) as the only rescue medication

Patients who have received rTMS within the past 6 months

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in San Diego?

Yes, this clinical trial (NCT07325513) has an active research site in San Diego, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Gulf War Illness Treatment Options in San Diego, CA

If you're searching for gulf war illness treatment options in San Diego, CA, this clinical trial (NCT07325513) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our San Diego research site is actively enrolling participants for this clinical trial. You'll receive care from experienced gulf war illness specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all gulf war illness clinical trials near you to find additional studies recruiting in your area.

Gulf War Illness Clinical Trial in San Diego, CA

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