San Francisco, CANCT07054801Now EnrollingIRB Ready

Headaches Associated With Subarachnoid Hemorrhage (SAH) Clinical Trial in San Francisco, CA

Access cutting-edge headaches associated with subarachnoid hemorrhage (sah) treatment through this phase 2 clinical trial at a research site in San Francisco. Study-provided care at no cost to qualified participants.

Sponsored by Daniel Raper, MBBS

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Expert Care in San Francisco

Access headaches associated with subarachnoid hemorrhage (sah) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related headaches associated with subarachnoid hemorrhage (sah) treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to San Francisco

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit San Francisco site if eligible
  4. 4Begin participation

About This Headaches Associated With Subarachnoid Hemorrhage (SAH) Study in San Francisco

Subarachnoid hemorrhage (SAH) is a type of bleeding around the brain that can cause sudden and severe headaches. These headaches can be debilitating and persist for weeks, significantly impacting a patient's comfort and recovery. Many patients require opioids for pain control, which can lead to side effects such as drowsiness, constipation, and dependency. There is a need for new treatment strategies to help relieve this pain while minimizing side effects. This clinical study is designed to evaluate whether an injection of two medications (lidocaine and methylprednisolone) directly into the middle meningeal artery (MMA) can help reduce headache severity in patients who recently experienced a SAH. The medications will be given through a minimally invasive procedure performed during a routine angiogram, a type of imaging test already commonly used in SAH patients. The main goals of the study are to determine whether this treatment approach is safe, helps to reduce the severity of headaches, and decreases the need for opioid pain medications. Eligible patients will be those recently diagnosed with persistent headache symptoms and SAH who are undergoing routine cerebral angiogram, during which the medications are infused into the MMA. Participants will be monitored for pain levels using the Headache Impact Test (HIT-6) and 11-point Numeric Rating Scale (NRS), and for changes in their functional recovery using standard neurologic scales. The results of this study may provide early evidence to support new treatment options for patients suffering from difficult-to-control headaches after a SAH.

Sponsor: Daniel Raper, MBBS

Who Can Participate

Inclusion Criteria

Adults aged ≥18 years with confirmed SAH via computed tomography or magnetic resonance imaging
Undergoing DSA as part of routine diagnostic or therapeutic care
Experiencing headaches with baseline severity assessable using Headache Impact Test (HIT-6) questionnaire and 11-point Numeric Rating Scale (NRS)
Conscious patients who can understand and sign informed consent form
Hemodynamically stable and suitable for intra-arterial procedures 5\) Willingness to comply with study procedures and follow-ups

Exclusion Criteria

Known allergy or hypersensitivity to lidocaine or amide-type anesthetics
Known allergy or hypersensitivity to Intralipid® (intravenous fat emulsion) or any of its components, including egg phospholipids or soy-based products
Known allergy or hypersensitivity to methylprednisolone, corticosteroids, any component of the Solu-Medrol® formulation
Diagnostic abnormalities at baseline, including ECG abnormalities (e.g., prolonged PR/QTc intervals, heart block, arrhythmias)
Cardiac conditions including history of heart block, Stokes-Adams syndrome, Wolff-Parkinson-White syndrome, or use of antiarrhythmics
Steroid-induced psychiatric history; uncontrolled seizures; uncontrolled diabetes; glaucoma/ocular hypertension; current/recent high-dose systemic steroids.
Previous IA lidocaine or methylprednisolone (or similar) therapy prior to enrollment
Alternative headache etiology (e.g., migraines, tension-type headache)
Unable to report pain reliably due to severe cognitive or communication deficits
Severe hemodynamic instability precluding safe DSA participation
Contraindications to IA catheterization or DSA (e.g., severe peripheral vascular disease, contrast allergies)
Severe renal impairment (eGFR \<30 mL/min/1.73 m²)
Severe hepatic impairment (e.g., Child-Pugh Class C)
Active systemic infections
Severe comorbid conditions with life expectancy \<30 days
Participants who are pregnant or breastfeeding
Conditions or concomitant medications listed in the USPI for study drugs that would compromise safety or data quality
Current participation in another clinical trial

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in San Francisco?

Yes, this clinical trial (NCT07054801) has an active research site in San Francisco, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Headaches Associated With Subarachnoid Hemorrhage (SAH) Treatment Options in San Francisco, CA

If you're searching for headaches associated with subarachnoid hemorrhage (sah) treatment options in San Francisco, CA, this clinical trial (NCT07054801) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our San Francisco research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced headaches associated with subarachnoid hemorrhage (sah) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all headaches associated with subarachnoid hemorrhage (sah) clinical trials near you to find additional studies recruiting in your area.

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