Houston, TXNCT05618353Now EnrollingIRB Ready

Heart Disease Clinical Trial in Houston, TX

Access cutting-edge heart disease treatment through this phase 4 clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by VA Office of Research and Development

Quick Self-Assessment

See if you qualify for this Houston location

Preparing your pre-screening questions…

Expert Care in Houston

Access heart disease specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related heart disease treatment provided free

Apply for This Houston Location

Check if you qualify for this heart disease clinical trial in Houston, TX

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Heart Disease Study in Houston

Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death. Patients with heart disease undergoing major surgery are at increased risk of complications after surgery, including heart attack, stroke, and death. The proposed research seeks to better understand the role of inflammation in the damage to the heart and blood vessels after major surgery. This research also seeks to identify the potential beneficial role

Sponsor: VA Office of Research and Development

Who Can Participate

Inclusion Criteria

Men and women with
Prior coronary revascularization (via PCI or coronary artery bypass graft surgery) or high coronary atherosclerotic burden (\>70% let main disease or \>80% disease in the proximal or mid LAD, prox Cx, or prox or mid RCA on coronary angiography), AND
Referred for intermediate- or high-risk surgery (general abdominal or intraperitoneal surgery, neurosurgery, suprainguinal surgery, peripheral vascular surgery, thoracic surgery).
If planned for only a laparoscopic or endovascular approach (this includes a minimally invasive hybrid approach such as transcarotid artery revascularization), at least one component of the Revised Cardiac Risk Index score (history of myocardial infarction, history of congestive heart failure, history of transient ischemic attack or stroke, pre-operative use of insulin, pre-operative creatinine \>2 mg/dL) should be present.

Exclusion Criteria

Colchicine use within one month or history of colchicine intolerance
Inflammatory bowel disease with history of diarrhea as presentation or chronic diarrhea
Pre-existent progressive neuromuscular disease
amyotrophic lateral sclerosis
hereditary muscular disorders
necrotizing myopathy
myasthenia gravis
lambert-eaton syndrome
Glomerular filtration rate \<30mL/minute or on dialysis
History of cirrhosis, chronic active hepatitis or severe hepatic disease
History of myelodysplasia with current evidence of cytopenia
Active infection defined as fever \>100.4oF or antibiotic use with white blood cell count greater than the upper limit of normal or lower than the lower limit of normal within 24 hours of randomization (major confounder with increased inflammatory markers)
Undergoing immunosuppressive or immunostimulatory chemo or biologic therapy
Pregnant (as confirmed by urine or serum test), nursing, or planning to become pregnant during study participation
Participating in a competing study or unable to consent
Any significant condition or situation that may put the participant at higher risk, confound the study results, or interfere with adherence to study procedures
Patients on strong CYP3A4 and/or P-glycoprotein inhibitors (e.g., ritonavir, clarithromycin, diltiazem, verapamil) at baseline will also be excluded due to potential drug interactions
However, if one of these medications are started during the post-operative study period, dose adjustments will be made per drug package insert
Participants will also be instructed not to drink grapefruit juice while on study drug

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT05618353) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Heart Disease Treatment Options in Houston, TX

If you're searching for heart disease treatment options in Houston, TX, this clinical trial (NCT05618353) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced heart disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all heart disease clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Houston, TX