A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease With Mild to Moderate Aortic Stenosis (EVOID-AS)
This is an adaptive Phase 2/3 multicenter, double-blind, placebo-controlled, randomized, parallel, 2 arm study to evaluate the efficacy and safety of DA-1229 compared to placebo in patients with calci...
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcifi...
Top Cities for Valvular Heart Disease Clinical Trials
Valvular Heart Disease clinical trials are recruiting across 19 cities. Here are the cities with the most active studies:
About Valvular Heart Disease
Valvular heart disease occurs when one or more heart valves do not function properly, disrupting blood flow through the heart. Common types include aortic stenosis and mitral regurgitation. Treatment ranges from monitoring to surgical valve repair or replacement.
Clinical trials are advancing new treatments for valvular heart disease. Currently, 2 studies are recruiting a combined 1,082 participants across the United States. Research is being conducted by 2 organizations including REDNVIA Co., Ltd., Novartis Pharmaceuticals.
2026 Valvular Heart Disease Research Landscape
As of March 2026, the valvular heart disease clinical trial landscape includes 2 actively recruiting studies across 19 cities in the United States. These studies are collectively seeking 1,082 participants, with an average enrollment target of 541 per study.
Research is being led by 2 different organizations, including REDNVIA Co., Ltd., Novartis Pharmaceuticals.
Geographically, valvular heart disease trials are most concentrated in Beverly Hills, California (2 trials); Phoenix, Arizona (1 trial); Los Angeles, California (1 trial); Aurora, Colorado (1 trial); Jacksonville, Florida (1 trial) and 7 other cities.
Featured Valvular Heart Disease Studies
Highlighted recruiting studies for valvular heart disease, selected by enrollment size and research scope.
A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease With Mild to Moderate Aortic Stenosis (EVOID-AS)
This is an adaptive Phase 2/3 multicenter, double-blind, placebo-controlled, randomized, parallel, 2 arm study to evaluate the efficacy and safety of DA-1229 compared to placebo in patients with calcific aortic valve disease with mild to moderate aortic stenosis. There are 2 arms in this study to which patients will be randomized in a ratio of 1:1 to receive the DA-1229 or placebo orally once dail...
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.
Frequently Asked Questions About Valvular Heart Disease Clinical Trials
Are there valvular heart disease clinical trials near me?
Yes, there are 2 valvular heart disease clinical trials currently recruiting across 19+ cities in the United States, including Beverly Hills, California; Phoenix, Arizona; Los Angeles, California. Browse the studies above to find one at a location convenient for you.
How do I join a valvular heart disease clinical trial?
To join a valvular heart disease clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are valvular heart disease clinical trials free?
Yes, participation in valvular heart disease clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of valvular heart disease treatments are being studied?
Current valvular heart disease clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 2 research organizations.
Is it safe to participate in valvular heart disease clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov