Improving Mobility After Revascularization in Peripheral Artery Disease
Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ische...
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinical...
Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone
The goal of this clinical trial is to learn if the Auryon Atherectomy System with balloon angioplasty safe and effective in treating lower limb blockages. The main question it aims to answer is: Is tr...
SMART Exercise for PAD
Supervised exercise therapy (SET), consisting of treadmill exercise conducted three times weekly at a center while supervised by healthcare personnel, is first line therapy for people disabled by lowe...
Response to Exercise and Nitric Oxide in PAD
RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether ex...
The COCOA-PAD II Trial
Among people with peripheral artery disease (PAD) age 55 and older, the investigators will test the hypothesis that PAD participants randomized to cocoa flavanols will have greater improvement or less...
Effects of Carnosine In Patients With Peripheral Arterial Disease Patients
The purpose of this study is to determine whether carnosine (a food ingredient found in chicken and red meat) supplementation (2 g) for 6 months in participants with non-claudication and claudication ...
Top Cities for Peripheral Artery Disease Clinical Trials
Peripheral Artery Disease clinical trials are recruiting across 17 cities. Here are the cities with the most active studies:
About Peripheral Artery Disease
Peripheral artery disease (PAD) is a circulatory condition where narrowed arteries reduce blood flow to the limbs, especially the legs. Common symptoms include leg pain when walking (claudication). Treatment includes lifestyle changes, medications, and sometimes procedures to improve blood flow.
Clinical trials are advancing new treatments for peripheral artery disease. Currently, 7 studies are recruiting a combined 1,604 participants across the United States. Research is being conducted by 4 organizations including Northwestern University, Mercator MedSystems, Inc., Angiodynamics, Inc. and 1 others.
2026 Peripheral Artery Disease Research Landscape
As of March 2026, the peripheral artery disease clinical trial landscape includes 7 actively recruiting studies across 17 cities in the United States. These studies are collectively seeking 1,604 participants, with an average enrollment target of 229 per study.
Research is being led by 4 different organizations, including Northwestern University, Mercator MedSystems, Inc., Angiodynamics, Inc., Shahid Baba.
Geographically, peripheral artery disease trials are most concentrated in Chicago, Illinois (8 trials); Louisville, Kentucky (3 trials); Minneapolis, Minnesota (2 trials); Tucson, Arizona (1 trial); Downey, California (1 trial) and 7 other cities.
Featured Peripheral Artery Disease Studies
Highlighted recruiting studies for peripheral artery disease, selected by enrollment size and research scope.
Improving Mobility After Revascularization in Peripheral Artery Disease
Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ischemia. However, supervised exercise is inaccessible or burdensome for most PAD patients. Investigators hypothesize that home-based exercise combined with lower extremity revascularization will significa...
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion revascularization, and clinically relevant target lesion occlusion after revascularization of lesions below the knee in patients with symptomatic Rutherford 3-5 peripheral arte...
Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone
The goal of this clinical trial is to learn if the Auryon Atherectomy System with balloon angioplasty safe and effective in treating lower limb blockages. The main question it aims to answer is: Is treatment with Auryon Atherectomy System more effective than angioplasty alone in preventing death, amputation, revascularization and improving patency? Researchers will compare the Auryon Atherectomy S...
Frequently Asked Questions About Peripheral Artery Disease Clinical Trials
Are there peripheral artery disease clinical trials near me?
Yes, there are 7 peripheral artery disease clinical trials currently recruiting across 17+ cities in the United States, including Chicago, Illinois; Louisville, Kentucky; Minneapolis, Minnesota. Browse the studies above to find one at a location convenient for you.
How do I join a peripheral artery disease clinical trial?
To join a peripheral artery disease clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are peripheral artery disease clinical trials free?
Yes, participation in peripheral artery disease clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of peripheral artery disease treatments are being studied?
Current peripheral artery disease clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 4 research organizations.
Is it safe to participate in peripheral artery disease clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 2, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 2, 2026 · Data from ClinicalTrials.gov