NCT05537467 · Maya Ignaszewski
Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients
(MUSIC-CPX)
What this study is about
The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.
View original scientific description
The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.
Interventions
OTHER
Music
Patients randomized to the music group will listen to upbeat music using headphones.
Primary outcome measures
Difference in O2 consumption (VO2) [L/min]
Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)
Assess above performance parameters in CPX and compare between Music and Non-Music arm.
Difference in CO2 production (VCO2) [L/min]
Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)
Assess above performance parameters in CPX and compare between Music and Non-Music arm.
Difference in respiratory exchange ratio (RER)
Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)
Assess above performance parameters in CPX and compare between Music and Non-Music arm.
Difference in Minute Ventilation (VE) [L/min]
Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)
Assess above performance parameters in CPX and compare between Music and Non-Music arm
Difference in Ventilatory Threshold (VT) [L]
Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)
Assess above performance parameters in CPX and compare between Music and Non-Music arm
Difference in respiratory rate (RR) [Breaths per minute]
Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)
Assess above performance parameters in CPX and compare between Music and Non-Music arm
Difference in Ventilatory Equivalent of CO2 (VE/VCO2)
Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)
Assess above performance parameters in CPX and compare between Music and Non-Music arm
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adults (age \>18 years)
- Able to consent
- English speaking
Exclusion criteria
- Severe hearing deficiency
- Unable to exercise.
Where
- Lexington, Kentucky
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 8, 2026 · Source of record for eligibility and locations