Springfield, ILNCT05839730Now EnrollingIRB Ready

Heart Failure With Preserved Ejection Fraction Clinical Trial in Springfield, IL

Access cutting-edge heart failure with preserved ejection fraction treatment through this clinical trial at a research site in Springfield. Study-provided care at no cost to qualified participants.

Sponsored by Medtronic Cardiac Rhythm and Heart Failure

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Expert Care in Springfield

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related heart failure with preserved ejection fraction treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Springfield

    Convenient for IL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Springfield site if eligible
  4. 4Begin participation

About This Heart Failure With Preserved Ejection Fraction Study in Springfield

FIRE-HFpEF is a multi-center, prospective, randomized, single-blinded, clinical feasibility study. This study will enroll up to 105 subjects with heart failure with preserved ejection fraction in the United States. Data will be collected to evaluate whether pacing therapies can lead to improvements in exercise capacity and health status of subjects.

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Who Can Participate

Inclusion Criteria

Diagnosis of Heart Failure, Left Ventricular Ejection Fraction (LVEF) ≥ 55% (this and other measurements must be made within the last year).
New York Heart Association (NYHA) Functional Class I-III
Stable on guideline-directed medical therapy (GDMT) heart failure medications as determined by the investigator, for at least 1 month, with the exception of loop diuretic therapy. GDMT should be in accordance with current American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Failure Society of America (HFSA) Guidelines and include consideration of Sodium/glucose cotransporter-2 inhibitors (SGLT2i) therapy.
V End Diastolic Volume indexed to body surface area (BSA) ≤ 80 mL/m\^2.
Concentric remodeling or concentric hypertrophy defined as at least one of the following criteria:
Left ventricular (LV) posterior or lateral wall thickness \> 11mm
Relative wall thickness (RWT) \> 0.42
Male and LV mass indexed to BSA ≥115 g/m2
Male and LV mass indexed to height ≥ 49.2 g/m2.7
Female and LV mass indexed to BSA ≥ 95 g/m2
Female and LV mass indexed to height ≥ 46.7 g/m2.7

Exclusion Criteria

Unable or unwilling to undergo contrast MRI.
Class I indication for permanent pacing, except for symptomatic chronotropic incompetence
Current permanent or persistent Atrial fibrillation (A-fib)
Structural heart disease requiring intervention
Aortic valve replacement procedure less than 12 months prior to enrollment
Known pericardial constriction, genetic hypertrophic cardiomyopathy, or infiltrative cardiomyopathy
Severe aortic or mitral valve disease, defined as severe regurgitation or a valve area \< 1cm\^2
Exertional angina
Severe pulmonary disease including severe Chronic obstructive pulmonary disease (COPD) (i.e., requiring home oxygen, chronic nebulizer therapy, or chronic oral steroid therapy or hospitalized for pulmonary decompensation within 12 months)
Estimated glomerular filtration rate (eGFR) \< 25 ml/min/1.73m\^2 as calculated by the Modification in Diet in Renal Disease (MDRD) formula
Uncontrolled blood pressure, defined as systolic pressure outside the range of 100 to 160 mmHg despite anti-hypertensive medication.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Springfield?

Yes, this clinical trial (NCT05839730) has an active research site in Springfield, IL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Heart Failure With Preserved Ejection Fraction Treatment Options in Springfield, IL

If you're searching for heart failure with preserved ejection fraction treatment options in Springfield, IL, this clinical trial (NCT05839730) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Springfield research site is actively enrolling participants for this clinical trial. You'll receive care from experienced heart failure with preserved ejection fraction specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all heart failure with preserved ejection fraction clinical trials near you to find additional studies recruiting in your area.

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