Is NCT07689175 recruiting in Dallas, TX?

Yes, NCT07689175 is currently recruiting participants at its Dallas, TX location. This hepatocellular carcinoma (hcc) clinical trial is actively enrolling qualified participants.

How do I join the hepatocellular carcinoma (hcc) clinical trial in Dallas?

To join this clinical trial in Dallas, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Dallas clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Hepatocellular Carcinoma (HCC) Clinical Trial in Dallas, TX

Who Can Participate

Inclusion Criteria

Patient must have a diagnosis confirmed by histology or clinically by the American Association for the Study of Liver Diseases (AASLD) criteria in patients with cirrhosis. Known fibrolamellar HCC or combined HCC-cholangiocarcinoma will be excluded.

Patients may not have received any prior anti-PD-1/L1 or anti-CTLA-4 therapies for the treatment of advanced HCC.

Patients with locally advanced or metastatic disease must have disease deemed not amenable to surgical and/or locoregional therapies or patients who have progressed following surgical and/or locoregional therapies.

Child-Pugh Score B7-8

Measurable disease, as defined as lesions that can accurately be measured in at least one dimension according to RECIST v.1.1.

Prior locoregional therapy is allowed provided the target lesion has increased in size ≥25% since the cessation of locoregional therapy or the target lesion was not treated with locoregional therapy. Patients treated with palliative radiotherapy for symptoms will be eligible as long as the target lesion is not the treated lesion.

Age ≥ 18 years.

ECOG performance score 0-2

Adequate organ and marrow function as defined below: Platelet count ≥ 40,000/mm3 Hgb ≥ 8 g/dl INR ≤ 2 AST, ALT ≤ 5 times ULN Calculated creatinine clearance (CrCl) ≥ 35 mL/min. CrCl can be calculated using the Cockcroft-Gault method. Albumin ≥ 2.0 g/dl

All men, as well as women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 120 days following completion of therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. 10a. A female of child-bearing potential is any woman (regardless of sexual orientation, marital status, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:

Has not undergone a hysterectomy or bilateral oophorectomy; or

Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months). 11\. Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria

Prior solid organ transplant.

Hypersensitivity to IV contrast; not suitable for pre-medication.

Subjects may not be receiving any other investigational agents for the treatment of the cancer under study.

Active autoimmune disease that requires current systemic treatment (ie, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs), except for conditions that, in the investigator's opinion, do not have a substantial hazardous risk such as asthma, and cutaneous and musculoskeletal rheumatologic conditions.

Known human immunodeficiency virus infection (testing not required) in a patient not on antiretroviral therapy and detectable viral load.

Prior malignancy that required systemic treatment within the previous year except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix, breast, or prostate cancer. Preneoplastic or malignant diagnoses that are indolent in nature and do not require active systemic treatment are not excluded.

If a participant has symptomatic or clinically active brain metastases including leptomeningeal disease, they must be excluded if:

Has evidence of progression by neurologic symptoms

Has metastatic brain lesions that require immediate intervention.

Has carcinomatous meningitis, regardless of clinical stability

Known severe hypersensitivity reactions to monoclonal antibodies (≥Grade 3).

Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that, in the opinion of the investigator, would limit compliance with study requirements.

Subjects must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.

Prisoners or subjects who are involuntarily incarcerated.

Has significant dementia or other mental condition that precludes the participant's ability to consent to the study.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Dallas?

Yes, this clinical trial (NCT07689175) has an active research site in Dallas, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Hepatocellular Carcinoma (HCC) Treatment Options in Dallas, TX

If you're searching for hepatocellular carcinoma (hcc) treatment options in Dallas, TX, this clinical trial (NCT07689175) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Dallas research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced hepatocellular carcinoma (hcc) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all hepatocellular carcinoma (hcc) clinical trials near you to find additional studies recruiting in your area.

Hepatocellular Carcinoma (HCC) Clinical Trial in Dallas, TX

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About This Hepatocellular Carcinoma (HCC) Study in Dallas