Rochester, MNNCT07223203Now EnrollingIRB Ready

Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy Clinical Trial in Rochester, MN

Access cutting-edge hereditary transthyretin-mediated amyloidosis with polyneuropathy treatment through this clinical trial at a research site in Rochester. Study-provided care at no cost to qualified participants.

Sponsored by Alnylam Pharmaceuticals

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Expert Care in Rochester

Access hereditary transthyretin-mediated amyloidosis with polyneuropathy specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related hereditary transthyretin-mediated amyloidosis with polyneuropathy treatment provided free

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Check if you qualify for this hereditary transthyretin-mediated amyloidosis with polyneuropathy clinical trial in Rochester, MN

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Why Participate?

  • No-Cost Study Care

  • Local to Rochester

    Convenient for MN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Rochester site if eligible
  4. 4Begin participation

About This Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy Study in Rochester

The purpose of this study is to: * Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment, quality of life, nutritional status, disability, and gait speed * Demonstrate superiority of nucresiran compared to in-study vutrisiran with respect to serum transthyretin (TTR) levels

Sponsor: Alnylam Pharmaceuticals

Who Can Participate

Inclusion Criteria

Has documented diagnosis of hATTR-PN
Has a diagnosis of hATTR amyloidosis with polyneuropathy with a documented TTR gene variant
Has a neuropathy impairment score (NIS) of 5 to 130 (inclusive)
Has a Karnofsky Performance Status (KPS) of ≥60%

Exclusion Criteria

Has had a liver transplant or is likely, in the opinion of the Investigator, to undergo liver transplantation during the Treatment Period of the study
Has known other (non-hATTR) forms of amyloidosis or clinical evidence of leptomeningeal amyloidosis
Has a New York Heart Association (NYHA) heart failure classification \>2
Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5 upper limit of normal (ULN)
Has total bilirubin \>1.5 ULN
Has estimated glomerular filtration rate (eGFR) ≤30 mL/min/1.73m\^2
Has other known causes of sensorimotor or autonomic neuropathy

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Rochester?

Yes, this clinical trial (NCT07223203) has an active research site in Rochester, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy Treatment Options in Rochester, MN

If you're searching for hereditary transthyretin-mediated amyloidosis with polyneuropathy treatment options in Rochester, MN, this clinical trial (NCT07223203) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Rochester research site is actively enrolling participants for this clinical trial. You'll receive care from experienced hereditary transthyretin-mediated amyloidosis with polyneuropathy specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all hereditary transthyretin-mediated amyloidosis with polyneuropathy clinical trials near you to find additional studies recruiting in your area.

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