Is NCT06428045 recruiting in Miami, FL?

Yes, NCT06428045 is currently recruiting participants at its Miami, FL location. This high grade glioma clinical trial is actively enrolling qualified participants.

How do I join the high grade glioma clinical trial in Miami?

To join this clinical trial in Miami, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Miami clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

High Grade Glioma Clinical Trial in Miami, FL

About This High Grade Glioma Study in Miami

The purpose of this study is to determine whether newly diagnosed high-grade glioma(s) that cannot be removed surgically change as a result of the study treatment; and to identify and evaluate the potential side effects (good and bad) of the study treatment in patients with newly diagnosed high-grade glioma(s) that cannot be removed surgically.

Sponsor: University of Miami

Who Can Participate

Inclusion Criteria

Age ≥ 18 years.

Patients with a histologically confirmed or suspected high-grade glioma (HGG) by MRI. a. For cases with suspected HGG, intraoperative frozen section diagnoses of HGG must be made by pathologists (Section 4.4.1).

Uni-focal or butterfly gliomas that can receive ≥70% of lesion volume ablated as determined by the treating surgeon.

Gliomas must be located or positioned where surgical resection is either not feasible or high-risk as deemed by a group of surgical neuro-oncologists.

Preoperative Karnofsky score ≥ 70 (APPENDIX A).

Patients must have demonstrable normal organ function as defined below within 14 days of surgery.

Absolute neutrophil count (ANC) ≥ 1500 cells/mm3

Platelets ≥ 100,000 cells/mm3

Hemoglobin ≥ 9.0 g/dL. Use of transfusion or other intervention to achieve this hemoglobin level is acceptable.

Blood urea nitrogen (BUN) ≤ 35 mg/dL and creatinine ≤ 1.9 mg/dL and estimated glomerular filtration rate (eGFR) or creatinine clearance rate \> 50 mL per minute.

Electrocardiogram (ECG) without evidence of acute cardiac ischemia.

Prothrombin time (PT)/International Normalized Ratio (INR) \<1.4

Liver function tests: Aspartate aminotransferase (AST) and alanine transaminase (ALT) at or below 2.5 times the upper limit of normal (ULN).

Sodium level \> 130 mg/L. Use of salt resection or hypertonic saline to achieve this sodium level is acceptable.

Patients must be able to understand and sign informed consent.

Exclusion Criteria

Patients with human leukocyte antigen (HLA) HLA-B\*5701 hypersensitivity (Section 10.1.6.7).

Patients with sensitivity to abacavir, lamivudine, or ritonavir (Section 7.3.1).

Patients with a previous history of HIV infection.

Patients with uncontrolled hepatitis B or C infection.

Patients who have received any surgical resection for this tumor. a. Patients who have received an open biopsy for this disease are still eligible for participation.

Patients who have received chemotherapy or radiation for this disease.

Patients who are taking dofetilide (Section 4.10.1).

Patients on a regimen of 1 or more prohibited medications as described in Section 4.10.1 that cannot be discontinued or switched to a more compatible medication. For more information on prohibited and precautionary use medications for patients on this study, please see Section 4.10.

Patients not eligible to obtain MRI with and without contrast.

Recurrent HGG.

Presence of current infection, such as sepsis, meningitis, bacteremia, or pneumonia.

Fever within 48 hours of surgery (Temperature\> 38.0°C).

Severe co-morbidity that would confer excess risk of surgery, radiation, or chemotherapy, as determined by the treating physician.

Any co-morbidity or psychiatric ailment that in the Investigator's opinion will prevent administration or completion of protocol therapy.

Pregnant women.

Patients must be willing to use contraception as described in Section 4.11.

Patients receiving other investigational agents or concurrent enrollment in another therapeutic clinical trial.

Adults unable to consent.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Miami?

Yes, this clinical trial (NCT06428045) has an active research site in Miami, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

High Grade Glioma Treatment Options in Miami, FL

If you're searching for high grade glioma treatment options in Miami, FL, this clinical trial (NCT06428045) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Miami research site is actively enrolling participants for this clinical trial. You'll receive care from experienced high grade glioma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all high grade glioma clinical trials near you to find additional studies recruiting in your area.

High Grade Glioma Clinical Trial in Miami, FL

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