Gainesville, FLNCT06246396Now EnrollingIRB Ready

Hypertension, Resistant to Conventional Therapy Clinical Trial in Gainesville, FL

Access cutting-edge hypertension, resistant to conventional therapy treatment through this phase 4 clinical trial at a research site in Gainesville. Study-provided care at no cost to qualified participants.

Sponsored by University of Florida

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Expert Care in Gainesville

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related hypertension, resistant to conventional therapy treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Gainesville

    Convenient for FL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Gainesville site if eligible
  4. 4Begin participation

About This Hypertension, Resistant to Conventional Therapy Study in Gainesville

The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension. The main questions it aims to answer are: * To what extent does minocycline lower blood pressure? * Are such blood pressure effects mediated through changes in gut microbiota, gut leakiness, systemic inflammation, neuroinflammation, or some combination of these? Participants will be randomly assigned to treatment with minocycline or placebo, treated daily for 3 months, to evaluate these questions.

Sponsor: University of Florida

Who Can Participate

Inclusion Criteria

Age ≥18 years
Uncontrolled TRH, defined as uncontrolled blood pressure (mean 24-hour ambulatory systolic BP ≥125 mm Hg or diastolic BP ≥80 mm Hg) while being adherent to a stable (no changes in ≥14 days prior) antihypertensive regimen of 3 or more drugs, including an adequately dosed diuretic or unable to tolerate a diuretic.
The participant agrees to have all study procedures performed

Exclusion Criteria

Known hypersensitivity or contraindication to minocycline or other tetracyclines
Recent (≤3 months prior), ongoing, or expected use of oral antibiotics
Estimated glomerular filtration rate (eGFR) of \<45mL/min/1.73m2, using the MDRD equation
Known secondary hypertension
History of hypertensive crisis, defined as any in-patient hospitalizations for hypertensive crisis/emergency within the past year
History of orthostatic hypotension, defined as two or more episode(s) of orthostatic hypotension (reduction of SBP of \>20 mm Hg or DBP of \>10 mm Hg within 3 minutes of standing) in the past year
History of myocardial infarction, unstable angina, syncope, or cerebrovascular accident in prior 6 months
Evidence of alcoholism or drug abuse
Severe comorbid conditions (i.e., neoplasms or HIV positive or AIDS)
Current pregnancy or anticipated pregnancy during the study.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Gainesville?

Yes, this clinical trial (NCT06246396) has an active research site in Gainesville, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Hypertension, Resistant to Conventional Therapy Treatment Options in Gainesville, FL

If you're searching for hypertension, resistant to conventional therapy treatment options in Gainesville, FL, this clinical trial (NCT06246396) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Gainesville research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced hypertension, resistant to conventional therapy specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all hypertension, resistant to conventional therapy clinical trials near you to find additional studies recruiting in your area.

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