NCT06735599 · Georgia State University
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
What this study is about
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
View original scientific description
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
Interventions
DIETARY_SUPPLEMENT
Wild Blueberry
Daily consumption of 22 g of freeze-dried wild blueberry freeze-dried powder for 8 weeks
DIETARY_SUPPLEMENT
Placebo
Daily consumption of 22 g of freeze-dried macronutrient-matched placebo powder for 8 weeks
Primary outcome measures
Ambulatory Blood Pressure
Time frame: Baseline, 4 weeks, and 8 weeks
Assessment of whole-day ambulatory blood pressure during daytime and nighttime periods.
Pulse Wave Velocity
Time frame: Baseline, 4 weeks, and 8 weeks
Arterial Stiffness will be measured by pulse wave velocity using SphygmCor
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Individuals 45-65 years of age
- Diagnosis of elevated blood pressure or stage 1 hypertension (systolic blood pressure = 120-139 mmHg and/or diastolic blood pressure = 80-89 mmHg) for at least 6 months
- BMI 25-35 kg/m2 via anthropometric measurements.
- Ability to give consent
Exclusion criteria
- Allergies to berries
- Use of one hypertensive drug for less than three months
- Use of more than one anti-hypertensive or statin drug, insulin, antibiotics, and anti-inflammatory drugs, active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological disorders or severe head injury
- Alcohol consumption (\>2 drinks/day)
- Consuming antioxidant, probiotic, and prebiotic supplements
- Pregnant or lactating
- Participating in a weight loss program
Where
- Atlanta, Georgia
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 27, 2026 · Source of record for eligibility and locations