NCT07124130 · Eastern Virginia Medical School
Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor
What this study is about
The goal of this clinical trial is to determine which of two types of standard given through a vein (IV) (IV) fluids (a combination of 5% dextrose and Lactated Ringers solution and Lactated Ringers solution alone) has a better influence on labor when inducing labor in pregnant women. The main questions it aims to answer are: 1.
View original scientific description
The goal of this clinical trial is to determine which of two types of standard intravenous (IV) fluids (a combination of 5% dextrose and Lactated Ringers solution and Lactated Ringers solution alone) has a better influence on labor when inducing labor in pregnant women. The main questions it aims to answer are: 1. Does the use of 5% dextrose and Lactated Ringers lead to a shorter labor than the use of just Lactated Ringers? 2. Does the use of 5% dextrose and Lactated Ringers increase the risk of neonatal hypoglycemia when compared to Lactated Ringers? Participants in this trial will be randomly assigned to one of two groups: a group that receives a solution of 5% dextrose and Lactated Ringers, and a group that receives Lactated Ringers alone. Researchers will compare the outcomes of the two groups to see which IV fluid is more effective.
Interventions
DRUG
5% Dextrose (D5) in Normal Saline (NS)
A solution of 5% dextrose and lactate ringer will be given to one group of participants.
DRUG
Lactate Ringer
A Lactate Ringer solution will be given to one group of participants.
Primary outcome measures
Time from Induction Start To Delivery
Time frame: From enrollment to the end of labor
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Nulliparous women
- Age 18 years or older and able to provide informed consent
- Singleton pregnancy at term
- Induction of labor
- Cephalic presentation
- Unfavorable cervix (Bishop score ≤ 6)
Exclusion criteria
- Age under 18 years
- Involuntarily confined or detained
- Considered as having diminished decision-making capacity
- Spontaneous labor (cervical exam between 5-6 cm) with or without ruptured membraned
- Favorable cervix (Bishop score \>6)
- Diabetes mellitus (both gestational and pre-gestational)
- Structural renal disease
- Acute or chronic kidney disease resulting in abnormal creatinine or proteinuria
- Evidence of chorioamnionitis or non-reassuring fetal testing at the time of enrollment
- Pyrexia (\>38.0 degrees Celsius)
- Planned cesarean delivery
- Women presenting with emergent circumstances for labor induction
Where
- Norfolk, Virginia
Collaborators
University of Modena and Reggio Emilia
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 22, 2025 · Source of record for eligibility and locations