NCT06417216 · Kevin Houston
Head-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies
(OCNP)
What this study is about
This study is investigating whether eye exercises for abducens palsy and internuclear ophthalmoplegia increase ocular range of motion in the paretic direction when performed in virtual reality under head-cancelled compared to head-active conditions.
View original scientific description
This study is investigating whether eye exercises for abducens palsy and internuclear ophthalmoplegia increase ocular range of motion in the paretic direction when performed in virtual reality under head-cancelled compared to head-active conditions.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Presence of OCNP in one eye with 50% range-of-motion limitation or worse
- Able to provide informed consent and will be able to fluently read and understand spoken English OCNP Group
Exclusion criteria
- Presence of bilateral OCNP
- Range of motion better than 50%
- Visual acuity worse than 20/100 in either eye
- Greater than 4-line difference in visual acuity between the eyes,
- Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset Participants will be excluded if they are unable to participate if inclusion criteria are not met. Normal Group Inclusion Criteria:
- Absence of OCNP or other neurological or neuro-ophthalmic diseases
- No strabismus
- Have normal or near-normal vision with glasses or contact lenses.
- Be able to provide informed consent and will be able to fluently read and understand spoken English Normal Group Exclusion Criteria:
- Visual acuity worse than 20/100 in either eye
- Greater than 4-line difference in visual acuity between the eyes
- Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset
- Known inability to tolerate visual testing of at least 20 minutes continuously.
Where
- Jacksonville, Florida
- Worcester, Massachusetts
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 6, 2026 · Source of record for eligibility and locations