Boston, MANCT07358195Now EnrollingIRB Ready

Kidney Failure Chronic Clinical Trial in Boston, MA

Access cutting-edge kidney failure chronic treatment through this early phase 1 clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

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Expert Care in Boston

Access kidney failure chronic specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related kidney failure chronic treatment provided free

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Check if you qualify for this kidney failure chronic clinical trial in Boston, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Kidney Failure Chronic Study in Boston

The primary objective is to assess the safety of the addition of venetoclax to reduced intensity conditioning for HLA-matched and haploidentical combined HSC and kidney transplantation as measured by stable full donor hematopoiesis and absence of CTCAE grade IV or V toxicity attributable to venetoclax.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Patient ages 18-70
Underlying hematological malignancy which is deemed as being potentially curable with allogeneic bone marrow or PBSC transplantation by the BMT voting team.
Hematological malignancies include, but are not limited to: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma, multiple myeloma (MM), myelodysplastic syndrome (MDS. Patient should be in a partial (PR) or complete remission (CR) at the time of the transplant.
Existence of an HLA-matched or haploidentical relative who passes standard donor evaluations for bone marrow and kidney donation
LVEF \> 40% as measured by echocardiography or MUGA
FEV1, FVC, and DLCO \> 50% of predicted as measured by standard PFTs
Total bilirubin \< 2.0 (unless diagnosis of Gilbert's or hemolysis is made) and AST, ALT, alkaline phosphatase all \< 5x institutions upper limit of normal
ABO compatibility in the host vs. graft direction
Men and women of reproductive potential must agree to use a reliable method of birth control during the treatment, and women should do so for a period of 1 year following the transplant.
Participants should be on dialysis or have a CrCl ≤ 35 ml/min
Life expectancy greater than 6 months
Recipient ability to understand and provide informed consent Donor Inclusion Criteria:
HLA matched or haploidentical relative as defined by 3/6, 4/6, or 5/6 HLA-matched at HLA -A, -B, or -DRB1 who is 18-70 years of age
ECOG performance status 0 or 1
Excellent health per conventional pre-donor history (medical and psychosocial evaluation) • Acceptable laboratory parameters (hematology in normal or near-normal range; liver function \< 3 times the upper limit of normal and normal creatinine)
Compatible ABO blood group
Negative donor lymphocyte cross match
No positive testing for active viral infection (Hepatitis B, Hepatitis C, HIV)
Donor ability to understand and provide informed consent
Meets standard institutional criteria for both bone marrow or peripheral blood stem cell (PBSC) and kidney donation

Exclusion Criteria

Active serious infection
Participation in other investigational drug use at the time of enrollment
Positivity for active infection with HIV, HCV, or HBV
ABO blood group incompatibility in the host-vs-graft direction

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT07358195) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Kidney Failure Chronic Treatment Options in Boston, MA

If you're searching for kidney failure chronic treatment options in Boston, MA, this clinical trial (NCT07358195) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this early phase 1 clinical trial. You'll receive care from experienced kidney failure chronic specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all kidney failure chronic clinical trials near you to find additional studies recruiting in your area.

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