Is NCT06859164 recruiting in Chicago, IL?

Yes, NCT06859164 is currently enrolling participants at its Chicago, IL location. This knee osteoarthritis clinical trial is accepting qualified participants.

How do I join the knee osteoarthritis clinical trial in Chicago?

To join this clinical trial in Chicago, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Chicago clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Knee Osteoarthritis Clinical Trial in Chicago, IL: Lipiodol (Phase 2)

About This Knee Osteoarthritis Study in Chicago

Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomized sham-controlled trial (RCT). The influence of psychosocial and psychocognitive factors, changes in analgesic use, and conditions of knee joint cartilage and effusion will similarly be explored to determine their impacts on perceived pain response to GAE.

Sponsor: University of Chicago

Who Can Participate

Inclusion Criteria

Patients aged 40-80

Bilateral or unilateral knee pain attributed to osteoarthritis (treat the knee with greater pain-if equal, patient chooses)

Grade 2-4 osteoarthritis on standing weight-bearing knee radiographs per the Kellgren-Lawrence grading scale

Knee pain \> 6 months, refractory to conservative non-operative management, and scored ≥ 4 on Visual Analog Scale (VAS) (e.g., rest, activity modification, weight control, bracing, supervised physical therapy, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, oral opiates, intra-articular hyaluronic acid, PRP, stem cells, and/or oral/injectable corticosteroids)

Refusal of intra-articular corticosteroid injection

Exclusion Criteria

Active malignancy

Active infection of the affected knee

Corticosteroid injection of the affected knee within 3 months of enrollment

Rheumatoid arthritis or other seronegative arthropathy

Previous surgery of the affected knee (e.g., meniscus repair, meniscectomy, anterior cruciate ligament (ACL)/posterior cruciate ligament (PCL) reconstruction, chondroplasty, microfracture, loose-body removal, synovectomy, lateral release, patellar/quadriceps tendon repair, total or partial knee replacement, osteotomy, cartilage transplant), except diagnostic arthroscopy

Grade 0-1 osteoarthritis per Kellgren-Lawrence grading scale of the affected knee

Pregnancy or expected pregnancy

GFR \< 60 mL/min/1.73 m²

Anaphylactic reaction to iodinated contrast

Moderate to severe pain in other ipsilateral lower-limb joints (ankle, hip) with VAS \> 4

Body weight \> 400 lbs (unsafe for angiography)

Peripheral arterial disease of the treated extremity (Rutherford Grade 2 or greater)

Type 1 diabetes mellitus

Long-acting corticosteroid use within 6 months (3 months for short-acting)

History or other evidence of acute kidney injury (AKI)

History of reaction to contrast media, bronchial asthma, or allergic disorders

History of hypersensitivity to gadolinium-based contrast agents (GBCAs)

Chronic widespread generalized pain \>4 on VAS pain scale, including neuropathic pain

Major depressive disorder within 2 years before screening

Other severe psychiatric disorder (e.g., schizophrenia, bipolar disorder)

Suicide attempt or suicidal behavior within 30 days before screening

Diagnosis of fibromyalgia

Considering total knee replacement in the next year

Any other condition, unwillingness, or inability that, in the investigator's opinion, could jeopardize the subject's safety or protocol compliance

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Chicago?

Yes, this clinical trial (NCT06859164) has an active research site in Chicago, IL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Knee Osteoarthritis Treatment Options in Chicago, IL

If you're searching for knee osteoarthritis treatment options in Chicago, IL, this clinical trial (NCT06859164) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Chicago research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced knee osteoarthritis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all knee osteoarthritis clinical trials near you to find additional studies recruiting in your area.

Knee Osteoarthritis Clinical Trial in Chicago, IL

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