Chicago, IL15 Active Studies

Osteoarthritis Clinical Trials in Chicago, IL

Find 15 actively recruiting osteoarthritis clinical trials in Chicago, IL. Connect with local research sites and explore new treatment options.

15
Active Trials
8
Sponsors
2,611
Enrolling

Recruiting Osteoarthritis Studies in Chicago

NCT07153471Recruiting

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have ost...

Chicago, ILPHASE3800 participantsEli Lilly and Company
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NCT06797245Recruiting

APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

The APPROVE trial is a multi-centered, randomized controlled trial designed to assess differences in symptom improvement, quality of life, bladder symptoms, satisfaction with treatment and continued t...

Chicago, ILNA596 participantsMedstar Health Research Institute
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NCT07219771Recruiting

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

This is a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of intra-articular administration of PTP-001 (MOTYS) for the treatment of knee osteoarthri...

Chicago, ILPHASE3260 participantsDoron Therapeutics Inc.
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NCT06245109Recruiting

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants w...

Chicago, ILPHASE4180 participantsNorthwestern University
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NCT07225829Recruiting

A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis

This phase 2a trial is an international, multicenter, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of one single intra-articular (IA) injection of 4P004 or...

Chicago, ILPHASE2129 participants4Moving Biotech
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NCT05985785Recruiting

Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection

Prospective single-masked (study participant will be masked), randomized controlled trial to examine the influence of BMAC on patient-reported outcomes (PROs) in patients with primary knee osteoarthri...

Chicago, ILNA100 participantsRush University Medical Center
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NCT06781463Recruiting

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

The goal of this study is to create a prospective registry (\<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoa...

Chicago, IL100 participantsUniversity of Chicago
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NCT06843980Recruiting

MOTION Clinical Trial

Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with no...

Chicago, ILNA100 participantsMoximed
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NCT06617871Recruiting

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

Knee replacement surgery can be performed in one of two ways. Traditionally the goal was for the new joint to be in a neutral position with respect to the femur (thigh bone). This is called Mechanical...

Chicago, ILNA95 participantsNorthwestern University
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NCT04828954Recruiting

Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb

Thumb carpometacarpal (CMC) osteoarthritis (OA) is common, seen frequently in middle-aged and elderly women. While a variety of surgical treatments have been described with none superior to any other,...

Chicago, ILNA90 participantsUniversity of Chicago
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NCT06859164Recruiting

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment fea...

Chicago, ILPHASE250 participantsUniversity of Chicago
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NCT06944392Recruiting

Evaluating Pumpkin Seed Oil Extract Supplementation on Bladder Function

This is a pilot study to assess using validated outcome measures how ingesting pumpkin seed oil extract supports patient bladder function in a United States population....

Chicago, ILNA40 participantsNorthwestern University
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NCT07224958Recruiting

ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA

The aim of this study is to conduct a comparative evaluation of the ROAM OA Single Upright Brace and the Ossur Unloader One Knee Brace in subjects with medial compartment osteoarthritis. The focus is ...

Chicago, ILNA30 participantsRush University Medical Center
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NCT07161505Recruiting

Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior

This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the appr...

Chicago, ILNA26 participantsNorthwestern University
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NCT07537153Recruiting

Genicular Artery Embolization for Knee Osteoarthritis

Patients will be asked to take part in this research study because they have mild-to-moderate knee osteoarthritis (OA) and were referred clinically for a procedure called Genicular Artery Embolization...

Chicago, ILNA15 participantsNorthwestern University
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About Osteoarthritis Clinical Trials in Chicago

Osteoarthritis is the most common form of arthritis, occurring when protective cartilage that cushions the ends of bones wears down over time. It most commonly affects joints in the hands, knees, hips, and spine. Treatment includes exercise, weight management, pain relief, and joint replacement surgery.

There are currently 15 osteoarthritis clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 2,611 participants. Research is being sponsored by Eli Lilly and Company, Medstar Health Research Institute, Doron Therapeutics Inc. and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Osteoarthritis Clinical Trials in Chicago — FAQ

Are there osteoarthritis clinical trials in Chicago?

Yes, there are 15 osteoarthritis clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What osteoarthritis treatments are being tested?

The 15 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for osteoarthritis.

Data updated July 18, 2026 from ClinicalTrials.gov