NCT06768762 · University of South Carolina
Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement
(MOST Energized)
What this study is about
The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines \[≥150 min/week of MVPA\]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.
View original scientific description
The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines \[≥150 min/week of MVPA\]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.
Interventions
BEHAVIORAL
Phone Coaching
Participants will receive 11 coaching calls with a health coach. Calls will occur weekly during the first month, twice/month during months 2-3, and once/month during months 4-6. Each call is expected to last 10-15 minutes.
BEHAVIORAL
Progress reports to providers
Progress reports on physical activity and program adherence will be sent to participants providers at 3 and 6 months.
BEHAVIORAL
'Hear from Others' Videos
Participants will receive monthly 'Hear From Others' videos. The videos will include other adults with knee replacement discussing the challenges they have faced and strategies to overcome barriers to activity.
BEHAVIORAL
Individualized Feedback
Participants will receive individualized feedback from a coach via email. The feedback will specifically focus on participant responses to the 'Apply Your Knowledge' activities and will correspond with the video lessons. Feedback will be weekly during months 1-3 and monthly during months 4-6.
BEHAVIORAL
Online exercise program
MOST Energized! Online Exercise Program
Primary outcome measures
Physical activity (min/week)
Time frame: Baseline to 6 months
Change in Actigraph-assessed moderate-to-vigorous intensity physical activity
Percentage meeting physical activity guidelines
Time frame: 6 months
Percentage of participants meeting physical activity guidelines (150 minutes/week)
Physical activity (min/week)
Time frame: Baseline to 12 months
Change in Actigraph-assessed moderate-to-vigorous intensity physical activity
Percentage meeting physical activity guidelines
Time frame: 12 months
Percentage of participants meeting physical activity guidelines (150 minutes/week)
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- had a knee replacement (including primary, staged or independent bilateral, or revision) at least 12 months ago
- have a computer, tablet, or smartphone with active internet access
- self-report engaging in less than 60 minutes/week of moderate-intensity physical activity
- be English-speaking and able to read consent and study materials written in English
- be willing to complete the 4 remote assessments, including physical activity monitoring
- be willing to be randomized to receive 0-4 supplemental intervention components.
Exclusion criteria
- any contraindications to physical activity (e.g., chest pain)
- have a scheduled surgery within the next 12 months (e.g., hip or knee replacement)
- have a mobility limiting comorbidity unrelated to knee replacement
- live outside of the continental U.S
- do not currently have a physician or orthopedic surgeon whom they see regularly
- are currently participating in physical therapy (for knee)
- are participating in a structured weight loss or physical activity program
- unable to provide proof of knee replacement surgery
- have a BMI \>40kg/m2
- score \>30 on PROMIS cognitive function
Where
- Columbia, South Carolina
Collaborators
National Institute on Aging (NIA)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 5, 2026 · Source of record for eligibility and locations