NCT07457567 · Yale University
Neural Mechanisms of the Social Brain
What this study is about
This study aims to understand the neural mechanisms that underlie synchronization of two brains during social interactions.
View original scientific description
This study aims to understand the neural mechanisms that underlie synchronization of two brains during social interactions.
Interventions
DEVICE
Transcranial Magnetic Stimulation (TMS)
TMS to targeted regions. Transcranial Direct Current Stimulation, tDCS, to targeted and sham regions.
Primary outcome measures
Percent change in hemodynamic signals
Time frame: Baseline and At time of measurement, approximately one hour
Statistical comparison of measures before and after stimulation. Measurement of brain oxygenation during cognitive assessment. The variable of interest will be changes in fNIRS oxyhemoglobin and deoxyhemoglobin signals (% change from baseline) during the cognitive assessment.
Electroencephalography (EEG) response to live face gaze
Time frame: At time of measurement, approximately one hour
Statistical comparison of measures before and after stimulation. EEG response to live face gaze is acquired for frequencies between 1 and 20 Hz. Oscillatory signals will be partitioned into Theta (4-8 Hz) and Alpha (8-12 Hz) frequencies for comparisons before and after TMS. Higher values indicate better score.
Eye Contact Behavior
Time frame: At time of measurement, approximately one hour
Statistical comparison of measures before and after stimulation (amplitude). Free viewing Eye tracking measures are detected by light reflections acquired at 120 Hz. Eye to eye contact is computationally determined by comparison of the eye tracking measures between the two partners.
Face Gaze Behavior
Time frame: At time of measurement, approximately one hour
Statistical comparison of measures before and after stimulation (Action Units). Facial dynamics are quantified by rapid photography and AI programs (OpenFace) that classify categories of facial expressions. There are 17 facial expressions that will be acquired during the face gaze conditions.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- -Self reported typically developed adults.
Exclusion criteria
- -No prior history of seizure activity. Self reported absence of recreational drugs at time of study.
Where
- New Haven, Connecticut
Collaborators
National Institute of Mental Health (NIMH)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 13, 2026 · Source of record for eligibility and locations