NCT06681818 · Englewood Hospital and Medical Center
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
What this study is about
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
View original scientific description
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
Interventions
OTHER
carbon monoxide measurement via smokerlyzer
participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection
Primary outcome measures
correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection
patients will be asked to donate exhaled breath into a smokerlyzer device
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Patient plans to have partial liver resection for primary liver pathology or metastatic disease
- Patient is able to comprehend and willing to sign the written consent form
Exclusion criteria
- Patients \< 18 years
- Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test
Where
- Englewood, New Jersey
Related conditions & keywords
Frequently asked questions
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A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
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Data: ClinicalTrials.gov · synced Jul 23, 2025 · Source of record for eligibility and locations