Miami, FLNCT05412082Now EnrollingIRB Ready

Locally Advanced Rectal Cancer Clinical Trial in Miami, FL

Access cutting-edge locally advanced rectal cancer treatment through this clinical trial at a research site in Miami. Study-provided care at no cost to qualified participants.

Sponsored by University of Miami

Quick Self-Assessment

See if you qualify for this Miami location

Preparing your pre-screening questions…

Expert Care in Miami

Access locally advanced rectal cancer specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related locally advanced rectal cancer treatment provided free

Apply for This Miami Location

Check if you qualify for this locally advanced rectal cancer clinical trial in Miami, FL

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Miami

    Convenient for FL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Miami site if eligible
  4. 4Begin participation

About This Locally Advanced Rectal Cancer Study in Miami

The purpose of this research study is to find out how safe and effective is treating patients with locally advanced rectal cancer (LARC) with chemotherapy first and then follow with radiation therapy to a higher dose than what is usually delivered and see if patients could have complete response and be spared from surgery.

Sponsor: University of Miami

Who Can Participate

Inclusion Criteria

Patients with newly diagnosed, biopsy proven, rectal adenocarcinoma.
Primary tumor located ≤18 cm from margin verge.
Primary tumor either a T3N0 or T1-4 N positive (as defined per pelvic MRI; nodes ≤ 15 mm).
≥ 18 years of age.
Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
Serum liver function tests values within the range of 1.5 x Upper Limit of Normal (within 6 weeks of enrollment).
Negative pregnancy test for women of child-bearing potential (within 4 weeks of enrollment).
Ability to understand and the willingness to sign a written informed consent document.
Patient is assessed by a surgeon, medical oncologist and a radiation oncologist and deemed fit for Total Neoadjuvant ChemoTherapy (TNT) and surgery.

Exclusion Criteria

Metastatic disease on initial work up (Chest and abdomen contrast enhanced CT scan).
Synchronous cancer found on colonoscopy.
Previous history of pelvic radiotherapy.
History of concurrent, active malignancy other than non-metastatic skin cancer within the last 2 years.
Symptomatic congestive heart failure of New York Heart Association Class III or IV, unstable angina pectoris or uncontrolled severe cardiac arrhythmia, myocardial infarction within the last 6 months.
Psychiatric illness/social situations that would limit compliance with study requirements.
Active (acute or chronic) or uncontrolled severe infections requiring intravenous antibiotics or active tuberculosis (TB).
Patients with poorly controlled acquired immune deficiency syndrome (AIDS) who are not deemed candidates for FOLFOX, mFOLFIRINOX or CAPOX chemotherapy. Active connective tissue disorders, such as lupus or scleroderma, that, in the opinion of the treating physician may put the patient at high risk for radiation toxicity.
Active connective tissue disorders, such as lupus or scleroderma, that in the opinion of the treating physician may put the patient at high risk for radiation toxicity
Sensory or motor neuropathy ≥ grade 2.
Women who are breast feeding.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Miami?

Yes, this clinical trial (NCT05412082) has an active research site in Miami, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Locally Advanced Rectal Cancer Treatment Options in Miami, FL

If you're searching for locally advanced rectal cancer treatment options in Miami, FL, this clinical trial (NCT05412082) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Miami research site is actively enrolling participants for this clinical trial. You'll receive care from experienced locally advanced rectal cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all locally advanced rectal cancer clinical trials near you to find additional studies recruiting in your area.

More Colorectal Cancer Trials in Miami, FL

See all colorectal cancer clinical trials recruiting in Miami — not just this study.

Browse Colorectal Cancer Trials in Miami →

Browse More Trials by Condition

Colorectal Cancer TrialsLeukemia TrialsAlzheimers Disease TrialsAtopic Dermatitis TrialsErectile Dysfunction TrialsAll Conditions →

Ready to Join in Miami?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Miami, FL