NCT07003113 · University of Illinois at Chicago
Ischemic Preconditioning in Osteoarthritis and Back Pain
What this study is about
We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.
View original scientific description
We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.
Interventions
DEVICE
Ischemic Preconditioning
The intervention arm will include full blood flow occlusion in one thigh for 5 minutes followed by 5 minutes of reperfusion for a cycle of 50 minutes.
DEVICE
Sham Intervention
This intervention includes 25mmHg of pressure, which is not sufficient for blodo flow occlusion.
Primary outcome measures
Preferred walking speed
Time frame: At baseline (from enrollment) until end of intervention (3 weeks).
Changes in preferred walking speed (m/s) from intervention
Muscle strength
Time frame: From baseline (enrollment) until end of intervention (3 weeks)
Change in quadriceps, hamstring, and hip strength
Patient Reported Outcomes
Time frame: At baseline (enrollment) through the intervention (3 weeks)
Change in subjective function and reporting based on questionnaires
Gait Kinematics
Time frame: At baseline (from enrollment) until end of intervention (3 weeks).
Changes in gait kinematics (in degrees) from intervention
Gait Kinetics/Moments
Time frame: At baseline (from enrollment) until end of intervention (3 weeks).
Changes in gait kinetics (joint moments) (in N/m) from intervention
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Reported Knee Pain using ACR Criteria
- Reported Back Pain using ODI Criteria \> 12
- Ability to walk for at least 3 minutes without the use of aids
- Ability to provide written informed consent
Exclusion criteria
- Younger than 50 years old
- History of Knee or Hip Replacements
- History of steroid injection within the previous 6 months
- Presence of neuromuscular joint condition that affects lower extremity function
- History of blood clots in the leg or any condition in which compression of the thigh is contraindicated
- History of heart failure or thrombosis
- Allergic to ultrasound gel
- History of spine surgery
- Non-English speaker
- Currently pregnant or intends to become pregnant during the study
Where
- Chicago, Illinois
Collaborators
National Institute on Disability, Independent Living, and Rehabilitation Research
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Nov 17, 2025 · Source of record for eligibility and locations