New York, NYNCT06889168Now EnrollingIRB Ready

Lymphangioleiomyomatosis (LAM) Clinical Trial in New York, NY

Access cutting-edge lymphangioleiomyomatosis (lam) treatment through this clinical trial at a research site in New York. Study-provided care at no cost to qualified participants.

Sponsored by Columbia University

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Expert Care in New York

Access lymphangioleiomyomatosis (lam) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related lymphangioleiomyomatosis (lam) treatment provided free

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Check if you qualify for this lymphangioleiomyomatosis (lam) clinical trial in New York, NY

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Why Participate?

  • No-Cost Study Care

  • Local to New York

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit New York site if eligible
  4. 4Begin participation

About This Lymphangioleiomyomatosis (LAM) Study in New York

Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that appears to behave like a slowly growing cancer. Since clinical progression is very slow, new blood tests have been used to speed the time required to find safe and effective medications. A large National Institute of Health study called MILES showed that sirolimus (also known as Rapamycin) improved lung function in individuals with LAM. Since most individuals with LAM and impaired lung function are now on sirolimus, future studies may prove more difficult. Laboratory studies suggested that Imatinib mesylate (imatinib), an FDA-approved drug for leukemia, initiates LAM cell death. A pilot trial with imatinib titled "Imatinib Mesylate for the treatment of Lymphangioleiomyomatosis" - (LAMP-1) was funded by the Department of Defense in 2016, and documented (1) the safety of use of tyrosine kinase inhibitors in patients with LAM; (2) the safety of concurrent use of tyrosine kinase and mTOR inhibitors; and, (3) short term variability in vascular endothelial growth factor D (VEGF-D) - a LAM biomarker, as a response to therapies. Due to the short-term LAMP-1 trial, LAMP-2 will be a longer-term 6-month clinical study evaluating the safety and tolerability of imatinib in patients with LAM. Patients that participate in the trial will come in for 5 office visits and check-up phone calls every 2 weeks over the course of 6 months.

Sponsor: Columbia University

Who Can Participate

Inclusion Criteria

Women 18 through 64 years of age (inclusive)
Pulmonary Function Test (PFT) with following criteria:
DLCO \>20% predicted and FVC \<90% OR
Post bronchodilator FEV1 between 30% and 90% predicted.
Confirmed or possible diagnosis of LAM
Willing to avoid grapefruit juice and St. John's wort while in the study
Able and willing to comply with the study procedures

Exclusion Criteria

Women who have or will undergo a transplant
Women who will undergo surgery
Women who are currently pregnant or plan on a pregnancy
Women who are currently breast feeding or lactating
Dementia or other cognitive dysfunction that, in the opinion of the investigator, would prevent the participant from consenting to the study or completing study procedures
Currently taking any of the following medications:
Antifungal Medications: Ketoconazole; Itraconazole ; Voriconazole.
Antibiotics for bacterial infections: Clarithromycin.
Analgesics to treat headaches/migraines: Dihydroergotamine; Dihydroergotamine intranasal
Antiretroviral protease inhibitors used in human immunodeficiency virus (HIV) infections: Atazanavir ; Nelfinavir; Indinavir; Ritonavir; Saquinavir
Anti-epileptic or seizure medications: Carbamazepine, Fosphenytoin; Oxcarbamazepine; Phenobarbital ; Phenytoin; Primidone
Anti-depressant medications: Nefazodone; St. John's wort
Targeted cancer drugs: Regorafenib; Venetoclax ; Cobimetinib
Ivabradine (used to treat chronic heart failure); Telithromycin (used to treat community acquired pneumonia); Lomitapide (treatment of familial hypercholesterolemia); Lonafarnib (Hutchinson-Gilford progeria syndrome); conivaptan (treat low sodium levels); flibanserin (management of hypoactive sexual desire disorder (HSDD)); Naloxegol (opioid-induced constipation); Warfarin (prevent blood clots); Lurasidone (schizophrenia and bipolar depression); Eliglustat (treatment of Gaucher's disease).
Non English speaking, illiterate, or other vulnerable persons will not be included among study subjects.
Any condition that in the opinion of the investigator might adversely influence the study outcome.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New York?

Yes, this clinical trial (NCT06889168) has an active research site in New York, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Lymphangioleiomyomatosis (LAM) Treatment Options in New York, NY

If you're searching for lymphangioleiomyomatosis (lam) treatment options in New York, NY, this clinical trial (NCT06889168) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New York research site is actively enrolling participants for this clinical trial. You'll receive care from experienced lymphangioleiomyomatosis (lam) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all lymphangioleiomyomatosis (lam) clinical trials near you to find additional studies recruiting in your area.

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