Cleveland, OHNCT06290687Now EnrollingIRB Ready

Malignant Neoplasm of Bladder Clinical Trial in Cleveland, OH

Access cutting-edge malignant neoplasm of bladder treatment through this clinical trial at a research site in Cleveland. Study-provided care at no cost to qualified participants.

Sponsored by Case Comprehensive Cancer Center

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Expert Care in Cleveland

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related malignant neoplasm of bladder treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Cleveland

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Cleveland site if eligible
  4. 4Begin participation

About This Malignant Neoplasm of Bladder Study in Cleveland

The goal of this clinical trial is to determine if a partial cystectomy with extended pelvic lymph node removal will be effective at treating Muscle-Invasive Bladder Cancer instead of a complete cystectomy with extended pelvic lymph node removal. This clinical trial aims to determine the safety and oncologic efficacy of the intervention, and to examine patient-reported quality of life outcomes in participants. Participants will receive the standard pre-surgery treatment for approximately 4 to 6 weeks. After the pre-surgery treatment is completed, participants will undergo a partial cystectomy with extended pelvic lymph node dissection. After surgery, participants will receive adjuvant systemic therapy.

Sponsor: Case Comprehensive Cancer Center

Who Can Participate

Inclusion Criteria

Subjects must have histologically confirmed urothelial carcinoma of the bladder, clinical stage T2-3N0M0. Micropapillary, glandular, squamous, and sarcomatoid histologic variants of urothelial carcinoma are allowed.
Subjects must have unifocal or limited multifocal disease amenable to complete surgical resection with partial cystectomy, as judged by the treating urologic oncologist.
Age \>18 years. Because of the rarity of this disease and limited data on treatment efficacy in subjects 18 years of age, children are excluded from this study.
Performance status - Karnofsky Performance Status ≥70 or Eastern Cooperative Oncology Group (ECOG) performance status Grade 0 or 1.
Subjects must have normal organ and marrow function as defined below:
Total bilirubin within normal limits
AST (SGOT) ≤ 2.5 X institutional upper limit of normal
ALT (SGPT) ≤ 2.5 X institutional upper limit of normal
Bone marrow:
Absolute neutrophil count (ANC) ≥ 1,500/mm3
Platelet count ≥ 80,000/mm3, Hemoglobin ≥ 9.0 g/dL
Subjects must have the ability to understand and the willingness to sign a written informed consent document.
Subjects must have tumor less than or equal to 5 cm in largest dimension as assessed radiographically.
Treatment naive for MIBC.

Exclusion Criteria

Presence of hydronephrosis.
Presence of multifocal disease that is not amenable to complete resection with partial cystectomy.
Presence of distant carcinoma in situ.
Presence of clinical N+ or M+ disease.
Presence of cT4+ disease.
Non-urothelial histology.
Concurrent upper tract (ureter or renal pelvis) or urethral urothelial carcinoma.
Subjects who are not surgical candidates due to competing medical comorbidities or who refuse surgical treatment.
Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the participant (eg, compromise the well-being) or that could prevent, limit, or confound the protocol-specified assessments.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cleveland?

Yes, this clinical trial (NCT06290687) has an active research site in Cleveland, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Malignant Neoplasm of Bladder Treatment Options in Cleveland, OH

If you're searching for malignant neoplasm of bladder treatment options in Cleveland, OH, this clinical trial (NCT06290687) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cleveland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced malignant neoplasm of bladder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all malignant neoplasm of bladder clinical trials near you to find additional studies recruiting in your area.

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