Coronado, CANCT07527910Now EnrollingIRB Ready

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Clinical Trial in Coronado, CA

Access cutting-edge metabolic dysfunction-associated steatotic liver disease (masld) treatment through this clinical trial at a research site in Coronado. Study-provided care at no cost to qualified participants.

Sponsored by Regeneron Pharmaceuticals

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Expert Care in Coronado

Access metabolic dysfunction-associated steatotic liver disease (masld) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related metabolic dysfunction-associated steatotic liver disease (masld) treatment provided free

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Check if you qualify for this metabolic dysfunction-associated steatotic liver disease (masld) clinical trial in Coronado, CA

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Why Participate?

  • No-Cost Study Care

  • Local to Coronado

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Coronado site if eligible
  4. 4Begin participation

About This Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Study in Coronado

This study will test a study drug called ALN-PNP with and without another drug that is used for controlling blood sugar, appetite, and weight (for example, tirzepatide), to see if it can help treat MASLD, also known as fatty liver disease. ALN-PNP reduces the amount of Patatin-like phospholipase domain-containing protein 3 (PNPLA3), a protein that liver cells make, which may help decrease liver fat if there is an abnormal PNPLA3 protein. The goal of this study is to understand the effect of ALN-PNP with or without tirzepatide on reducing liver fat. The study is looking at: * How well ALN-PNP with and without tirzepatide works * What side effects ALN-PNP might cause * How much ALN-PNP is in the blood at different times * How the body and the liver change after having ALN-PNP, which can help researchers understand why ALN-PNP works better in some people than others

Sponsor: Regeneron Pharmaceuticals

Who Can Participate

Inclusion Criteria

Part A and Part B:
Homozygous for the PNPLA3 p.I148M genotype
Liver fat by Magnetic Resonance Imaging-Proton Density Fat Fraction (MRI-PDFF) ≥15% at visit 3
Has a Body Mass Index (BMI) ≥30 to \<45 kg/m\^2 at visit 2 Part A: To be eligible for randomization on study day 1:
Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) ≤3 × Upper Limit of Normal (ULN) as described in the protocol
On a stable dose of tirzepatide at randomization (≥5 mg weekly) Key

Exclusion Criteria

Evidence or diagnosis of portal hypertension or cirrhosis from any cause, including cirrhosis due to MASH, as determined by the investigator, based on medical history, clinical assessment, imaging, and/or liver biopsy
Known chronic liver disease other than MASLD, as determined by the investigator, as defined in the protocol
Contraindications to MRI examinations, including but not limited to persons with MRI-incompatible cardiac pacemaker and implants made of metal, severe claustrophobia, size restrictions
Any contraindication listed in the Zepbound United States Prescribing Information (USPI), as defined in the protocol NOTE: Other protocol-defined inclusion/exclusion criteria apply.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Coronado?

Yes, this clinical trial (NCT07527910) has an active research site in Coronado, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Treatment Options in Coronado, CA

If you're searching for metabolic dysfunction-associated steatotic liver disease (masld) treatment options in Coronado, CA, this clinical trial (NCT07527910) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Coronado research site is actively enrolling participants for this clinical trial. You'll receive care from experienced metabolic dysfunction-associated steatotic liver disease (masld) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all metabolic dysfunction-associated steatotic liver disease (masld) clinical trials near you to find additional studies recruiting in your area.

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