Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Non-Alcoholic Fatty Liver Disease Clinical Trials
Non-Alcoholic Fatty Liver Disease clinical trials are recruiting across 64 cities. Here are the cities with the most active studies:
Non-Alcoholic Fatty Liver Disease Trial Phases
33 research organizations are sponsoring non-alcoholic fatty liver disease trials.
About Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD/MASLD) is a condition where excess fat builds up in the liver without significant alcohol consumption. It is the most common liver disease in Western countries. Management includes weight loss, exercise, and treatment of associated metabolic conditions.
Clinical trials are advancing new treatments for non-alcoholic fatty liver disease. Currently, 39 studies are recruiting a combined 13,706 participants across the United States. Research is being conducted by 33 organizations including Eli Lilly and Company, 89bio, Inc., AdventHealth Translational Research Institute and 30 others.
2026 Non-Alcoholic Fatty Liver Disease Research Landscape
As of July 2026, the non-alcoholic fatty liver disease clinical trial landscape includes 39 actively recruiting studies across 64 cities in the United States. These studies are collectively seeking 13,706 participants, with an average enrollment target of 351 per study.
The research spans multiple phases of development: 10 studies are in NA, 9 studies are in PHASE2, 5 studies are in PHASE3, 2 studies are in PHASE4, 2 studies are in PHASE1, 1 study is in EARLY_PHASE1. The presence of Phase 3 trials indicates that some non-alcoholic fatty liver disease treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 33 different organizations, including Eli Lilly and Company, 89bio, Inc., AdventHealth Translational Research Institute, GlaxoSmithKline, Mayo Clinic, and 28 others. The large number of sponsors reflects significant research interest and investment in non-alcoholic fatty liver disease treatment advancement.
Geographically, non-alcoholic fatty liver disease trials are most concentrated in San Antonio, Texas (4 trials); San Francisco, California (4 trials); Boston, Massachusetts (3 trials); La Jolla, California (3 trials); New York, New York (3 trials) and 7 other cities.
Featured Non-Alcoholic Fatty Liver Disease Studies
Highlighted recruiting studies for non-alcoholic fatty liver disease, selected by enrollment size and research scope.
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
The main purpose of the SYNERGY-OUTCOMES study is to find out whether retatrutide and tirzepatide can prevent major adverse liver outcomes (MALO) in people with high-risk metabolic dysfunction-associated steatotic liver disease (MASLD). The study will enroll adults who have MASLD based on non-invasive tests (NITs), which indicate they are more likely to develop MALO. Participants will be randomly ...
A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
The study will assess the efficacy and safety of 2 dose regimens of pegozafermin for the treatment of liver fibrosis stage 2 or 3 in adult participants with MASH (previously known as nonalcoholic steatohepatitis \[NASH\]).
AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry (AVAIL)
The purpose of this study is to create a resource that will advance research that is focused on discovery of novel therapies, risk stratification, and aggressive interventions for those at highest risk for non-alcoholic fatty liver disease (NAFLD). To achieve this, we will generate a biobank of liver tissue collected during standard of care liver biopsies. Paired blood/urine samples, FibroScan and...
Frequently Asked Questions About Non-Alcoholic Fatty Liver Disease Clinical Trials
Are there non-alcoholic fatty liver disease clinical trials near me?
Yes, there are 39 non-alcoholic fatty liver disease clinical trials currently recruiting across 64+ cities in the United States, including San Antonio, Texas; San Francisco, California; Boston, Massachusetts. Browse the studies above to find one at a location convenient for you.
How do I join a non-alcoholic fatty liver disease clinical trial?
To join a non-alcoholic fatty liver disease clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are non-alcoholic fatty liver disease clinical trials free?
Yes, participation in non-alcoholic fatty liver disease clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of non-alcoholic fatty liver disease treatments are being studied?
Current non-alcoholic fatty liver disease clinical trials are testing a range of approaches across NA (10 studies), PHASE2 (9 studies), PHASE3 (5 studies), PHASE4 (2 studies), PHASE1 (2 studies), EARLY_PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 33 research organizations.
Is it safe to participate in non-alcoholic fatty liver disease clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov