Is NCT07136181 recruiting in Scottsdale, AZ?

Yes, NCT07136181 is currently recruiting participants at its Scottsdale, AZ location. This metastatic uveal melanoma clinical trial is actively enrolling qualified participants.

How do I join the metastatic uveal melanoma clinical trial in Scottsdale?

To join this clinical trial in Scottsdale, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Scottsdale clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Metastatic Uveal Melanoma Clinical Trial in Scottsdale, AZ

About This Metastatic Uveal Melanoma Study in Scottsdale

This study is being done to find the best dose of an investigational drug called NBM-BMX for people with metastatic uveal melanoma, a type of eye cancer that has spread to other parts of the body. The study will help doctors learn about the side effects of NBM-BMX, how the drug is processed in the body, and whether it may slow down or shrink tumors. Participants will take NBM-BMX as a capsule by mouth twice daily on an empty stomach with at least six ounces (180 mL) of water. No food or drink (other than water) should be consumed for at least two hours after each dose. Participants will visit the clinic about once every week or two for exams and blood tests while taking NBM-BMX. After stopping treatment, a follow-up visit will occur about 30 days later. Treatment may continue as long as the cancer does not get worse and side effects remain manageable.

Sponsor: Novelwise Pharmaceutical Corporation

Who Can Participate

Inclusion Criteria

\- Patients must meet the following criteria to be eligible for study entry:

Signed, written IRB-approved informed consent.

Men and women age ≥ 18 years

ECOG Performance status ≤ 2

Have measurable disease based on RECIST 1.1

Histologic or cytologic confirmation of metastatic uveal melanoma

Previous Therapy

Surgery: Previous surgery is permitted provided that a minimum of 28 days (4 weeks) has elapsed between any major surgery and date of registration, and that wound healing has occurred.

Cytotoxic Chemotherapy: There is no limit to the number of prior regimens received.

Other Systemic Therapy: There is no limit to the number of prior therapies received for metastatic uveal melanoma. Prior treatment with tebentafusp is required for HLA-A\*02:01-positive patients unless unavailable or clinically inappropriate, as determined by the investigator. Prior HDAC inhibitor treatment is not permitted. Patients must have recovered (to baseline or ≤ grade 1) from all reversible toxicity related to prior chemotherapy or systemic therapy and have adequate washout as follows: Longest of one of the following:

5 half-lives for investigational agents, o For anti-cancer therapies with half-lives \> 8 days, a washout period of at least 28 days will be acceptable,

Standard cycle length of standard therapies.

QTcF \<= 480 msec

Adequate hematopoietic capacity, as defined by the following:

Hemoglobin ≥ 9.0 g/dL and not transfusion dependent

Platelets ≥ 100,000/mm3

Absolute neutrophil count ≥ 1,500 cells/mm3

Adequate hepatic function, as defined by the following:

AST and ALT ≤ 2.5 times upper limit of normal (ULN) or ≤ 5 times ULN if liver metastases are present

Total bilirubin ≤ 1.5 x ULN or within 3x the ULN for patients with Gilbert disease

Albumin ≥ 3.0 g/dL

Adequate renal function, as defined by the following: \- Renal: calculated creatinine clearance \>45 mL/min for patients between 18 and 70 years old with abnormal, increased, creatinine levels (Cockcroft-Gault formula; Appendix F). For patients who are greater than 70 years old, investigator judgment may be used to assess the renal risk of study participation.

Women/men of childbearing potential must have agreed to use two effective contraceptive methods while on study and for 6 months after the last dose of NBM-BMX.

Willingness and ability to comply with the study scheduled visits, treatment plans, laboratory tests and other procedures.

Exclusion Criteria

Patients who meet the following criteria will be excluded from study entry:

Pregnant or nursing women. NOTE: Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation and for at least 6 months after the last dose of NBM-BMX. Should a man father a child, or a woman become pregnant or suspect she is pregnant while participating in this study, he or she should inform the treating physician immediately.

Concurrent non-protocol-specified anti-tumor therapy (e.g., chemotherapy, other targeted therapy, radiation therapy, or photodynamic therapy)

History of other malignancies within 3 years of Day 1, except for tumors with a negligible risk for metastasis or death, such as adequately treated squamous-cell carcinoma of the skin, ductal carcinoma in situ of the breast, or carcinoma in situ of the cervix.

Active or uncontrolled infections or with serious illnesses or medical conditions which would not permit the patient to be managed according to the protocol.

History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates use of an investigational drug or that might affect interpretation of the results of the study or renders the patient at high risk from treatment complications.

Difficulty with swallowing oral medications.

Currently taking moderate and strong inhibitors (e.g., gemfibrozil) or inducers of CYP2C8.

A positive test for hepatitis B (HBsAg) and/or hepatitis C (anti-HCV antibody), unless the HBV DNA level and/or HCV RNA level is below the limit of detection.

Any of the following within 3 months of the first dose of NBM-BMX: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, congestive heart failure, or cerebrovascular accident including transient ischemic attack.

Current use or anticipated need for P-gp or BCRP inhibitors during the study period.

Use of proton pump inhibitors (PPIs), H2-receptor antagonists, or other systemic acid-reducing agents within 7 days prior to Cycle 1 Day 1 or planned use during the study treatment period, unless the patient can be switched to local antacids (e.g., calcium carbonate or aluminum hydroxide) taken at least 2 hours before or after NBM-BMX dosing. Patients unable or unwilling to comply with this restriction should be excluded. Exceptions must be discussed with and approved by the Medical Monitor.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Scottsdale?

Yes, this clinical trial (NCT07136181) has an active research site in Scottsdale, AZ that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Metastatic Uveal Melanoma Treatment Options in Scottsdale, AZ

If you're searching for metastatic uveal melanoma treatment options in Scottsdale, AZ, this clinical trial (NCT07136181) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Scottsdale research site is actively enrolling participants for this clinical trial. You'll receive care from experienced metastatic uveal melanoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all metastatic uveal melanoma clinical trials near you to find additional studies recruiting in your area.

Metastatic Uveal Melanoma Clinical Trial in Scottsdale, AZ

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