NCT06904287 · Wake Forest University Health Sciences
Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines
(MAGraine2)
What this study is about
The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.
View original scientific description
The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.
Interventions
DRUG
Magnesium
Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by magnesium 2 g administered as an intravenous bolus over a period of 20 minutes
DRUG
Placebo
Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by placebo (normal saline)
Primary outcome measures
Mean change in pain - baseline to 30 minutes
Time frame: Baseline to 30 minutes after initiation of infusion
Change in pain score 30 minutes after initiation of infusion. Pain score is measured on a 0-11 point pain intensity numerical rating scale where 0=no pain and 10=worst possible pain.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age ≥ 18 years or older
- Able to provide informed consent
- English speaking
- Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical
Exclusion criteria
- of migraine mimics Exclusion Criteria:
- Pregnancy defined as a positive urine HCG
- Allergy or sensitivity to study drug
- Stated history of renal insufficiency
- Documented history of myasthenia gravis
- Consumption of study drug within 48 hours prior to enrollment
- Previously enrolled in this trial during a different patient encounter
Where
- Oak Lawn, Illinois
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 22, 2026 · Source of record for eligibility and locations