NCT06016465 · Texas Tech University Health Sciences Center, El Paso
Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
What this study is about
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
View original scientific description
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
Interventions
DRUG
Dexamethasone Oral
Two 4mg pills
DRUG
Placebo
2 placebo pills
Primary outcome measures
Recurrence of headache
Time frame: 72-96 hours post treatment
Subjects will be contacted 72 hrs post treatment to determine if migraine headache has recurred
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Meet ICHD-3 Migraine Headache Criteria
- Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2
- Nerve block performed with bupivacaine 0.5%
Exclusion criteria
- Head trauma
- Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma)
- Headache in the setting of viral syndrome
- Chronically on steroids
- Known allergy to dexamethasone
- Unable to reach the patient by phone or text for follow-up
- Gestational diabetes or other uncontrolled diabetes
- Known to be immunocompromised
Where
- El Paso, Texas
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 6, 2026 · Source of record for eligibility and locations