Brooklyn, NYNCT06473597Now EnrollingIRB Ready

Migraine Clinical Trial in Brooklyn, NY

Access cutting-edge migraine treatment through this clinical trial at a research site in Brooklyn. Study-provided care at no cost to qualified participants.

Sponsored by Antonios Likourezos

Quick Self-Assessment

See if you qualify for this Brooklyn location

Preparing your pre-screening questions…

Expert Care in Brooklyn

Access migraine specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related migraine treatment provided free

Apply for This Brooklyn Location

Check if you qualify for this migraine clinical trial in Brooklyn, NY

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Brooklyn

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Brooklyn site if eligible
  4. 4Begin participation

About This Migraine Study in Brooklyn

Rimegepant (Nurtec) is an orally administered small molecule CGRP receptor antagonist with efficacy in the acute treatment of migraine. Rizatriptan benzoate (MAXALT), is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. Rizatriptan binds with high affinity to human cloned 5-HT1B and 5-HT1D receptors which leads to activation of these receptors results in cranial vessel constriction, inhibition of neuropeptide release and reduced transmission in trigeminal pain pathways with resultant relieve of the headache. Teh investigators hypothesize that the administration of Rimegepant ODT would provide better analgesic efficacy than Rizatriptan ODT with respect to analgesic efficacy at 60 min and 120 minutes in ED patients with acute headache. This is a prospective, randomized, double-blind superiority trial evaluating and comparing analgesic efficacy and safety of Rimegepant ODT 75 mg to Rizatriptan ODT 10 mg in adult patients presenting to the Emergency Department of Maimonides Medical Center with acute migraine headache.

Sponsor: Antonios Likourezos

Who Can Participate

Inclusion Criteria

Adult ED patients age 18 to 65 years old
Acute headache
Initial Pain score of 5 on a standard 11- point (score 0 to 10) numeric rating scale
Patients will have to be awake, alert, and oriented to person, place, and time
Patients able to demonstrate understanding of the informed consent process and content.
Patients also will have to demonstrate ability to verbalize the nature of any adverse effects they might experience as well as to express their pain severity by using the NRS.

Exclusion Criteria

Allergy to Rimegepant or Rizatriptan
Pregnancy and breastfeeding
Unstable vital signs
Inability to provide consent
Suspicion for disease process other than migraine (those requiring emergent brain imaging, with a temperature of 100.4 °F, with objective neurologic findings, secondary headache (an "organic" headache))
Ischemic coronary artery disease (angina pectoris, history of myocardial infarction), coronary artery vasospasm (including Prinzmetal's angina)
History of stroke or transient ischemic attack
Peripheral vascular disease
Ischemic bowel disease,
Uncontrolled hypertension
Use of another 5-HT1 agonist, ergotamine-containing medications, or ergot-type medications (methylsergide)
Hemiplegic or basilar migraine
Concurrent administration or recent discontinuation (within 2 weeks) of a MAO-A inhibitors
Current use of Rimegepant as a prophylactic
Severe Nausea and Vomiting
Severe headache requiring immediate intervention
Severe hepatic impairment
If taking any of the following medications (contraindications):
Monoaminoxidaze (MAO) inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine)
SSRI- Citalopram, Escitalopram, Sertraline
Triptans: Sumatriptan, Zolmitriptan, Imigran
Almotriptan.
Cabergoline.
Dihydroergotamine.
Dihydroergotamine intranasal
Ergoloid mesylates
Frovatriptan
Cyclobenzaprine
Fluoxetine, velafaxine
TCA: nortriptyline (Pamelor), amitriptyline, protriptyline
Amphetamines: methamphetamine (Desoxyn), dextroamphetamine (Adderall, Adderall XR), dextroamphetamine (Dexedrine)
azole antifungals ( ketoconazole, itraconazole)
macrolide antibiotics (clarithromycin, erythromycin)
rifamycins (such as rifampin, rifabutin)
carbamazepine, phenytoin
Cardiac Drug: amiodarone (Nexterone, Pacerone), quinidine, ranolazine (Aspruzyo Sprinkle), verapamil (Verelan, Verelan PM)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Brooklyn?

Yes, this clinical trial (NCT06473597) has an active research site in Brooklyn, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Migraine Treatment Options in Brooklyn, NY

If you're searching for migraine treatment options in Brooklyn, NY, this clinical trial (NCT06473597) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Brooklyn research site is actively enrolling participants for this clinical trial. You'll receive care from experienced migraine specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all migraine clinical trials near you to find additional studies recruiting in your area.

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Ready to Join in Brooklyn?

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Secure · Expert Care · Brooklyn, NY