Boston, MANCT04124029Now EnrollingIRB Ready

Mild Traumatic Brain Injury Clinical Trial in Boston, MA

Access cutting-edge mild traumatic brain injury treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by VA Office of Research and Development

Quick Self-Assessment

See if you qualify for this Boston location

Preparing your pre-screening questions…

Expert Care in Boston

Access mild traumatic brain injury specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related mild traumatic brain injury treatment provided free

Apply for This Boston Location

Check if you qualify for this mild traumatic brain injury clinical trial in Boston, MA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Mild Traumatic Brain Injury Study in Boston

This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.

Sponsor: VA Office of Research and Development

Who Can Participate

Inclusion Criteria

All Subjects:
Intact color vision
Visual acuity of 20/30 (or better)
Patients must pass effort measures on the TOMM
Patients must have intact decision-making capacity
Patients must have no contraindications to lumbar puncture including:
Being on a blood thinner
Aspirin or Plavix
Have no space occupying lesion on magnetic resonance imaging (MRI)
An International Normalized Ratio (INR) value \< 1.4 and platelet count \>50,000
No epidural infection or overlying cellulitis over the lumbar spine
PTSD will be accounted for as a potential confounder and its presence will be included as a covariate in all analyses Mild TBI Subjects:
Subjects will be recruited who have a physician diagnosis of 1 or more mTBI episodes without concomitant moderate or severe TBI diagnosis
Mild TBI: Loss of consciousness greater than 30 minutes, posttraumatic amnesia greater than 24 hours, and/or altered mental status greater than 24 hours Moderate TBI Subjects:
Subjects will be recruited who have a physician diagnosis of 1 or more moderate TBI episodes
Moderate TBI: loss of consciousness greater than 30 minutes, posttraumatic amnesia greater than 24 hours, and altered mental status greater than 24 hours MCI Subjects:
Subjects will be recruited that meet diagnostic criteria for MCI (without a history of TBI) based on the judgement of a behavioral neurologist following the 2011 MCI criteria
Specifically, subjects will test in the impaired range on one or more cognitive domains on neuropsychological testing and will not have impairments in function, i.e. will not meet diagnostic criteria for dementia
Subjects with MCI may or may not meet diagnostic criteria for MCI due to AD
MCI subjects will be matched for their MoCA score with older TBI subjects Healthy Controls:
Cognitively normal control subjects, age-, education- and sex-matched with mild TBI subjects, but lacking and TBI history
All subjects must be within 1 standard deviation of normal on all neuropsychologic testing in order to be enrolled The investigators will recruit all subjects without regard to gender, race, ethnicity, socioeconomic status, or other factors to allow results of this research to yield the greatest generalizability

Exclusion Criteria

All Subjects:
If the primary language is not English
Are unable to understand the informed consent process
Have a clinically significant problem with any of the following conditions:
A history of TBI within 1 year of study
Suicidal or homicidal ideation requiring intervention
Schizophrenia
Bipolar disorder
Active alcohol or drug abuse
Clinically significant neurological disease other than those stated in the inclusion criteria
Impaired decision-making ability
Patients will be excluded if there are contraindications to MRI including:
Aneurysm clips
Non-TBI subjects must not have had an TBI
No contraindication to lumbar puncture or blood draw including:
Being on a blood thinner
Aspirin or Plavix
No space occupying lesion on MRI that makes lumbar puncture contraindicated

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT04124029) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Mild Traumatic Brain Injury Treatment Options in Boston, MA

If you're searching for mild traumatic brain injury treatment options in Boston, MA, this clinical trial (NCT04124029) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced mild traumatic brain injury specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all mild traumatic brain injury clinical trials near you to find additional studies recruiting in your area.

More Heart Attack Trials in Boston, MA

See all heart attack clinical trials recruiting in Boston — not just this study.

Browse Heart Attack Trials in Boston →

Browse More Trials by Condition

Heart Attack TrialsTraumatic Brain Injury TrialsRheumatoid Arthritis TrialsInterstitial Cystitis TrialsMyocardial Infarction TrialsInterstitial Lung Disease TrialsAll Conditions →

Ready to Join in Boston?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Boston, MA