Baltimore, MDNCT06170970Now EnrollingIRB Ready

Multiple Sclerosis Clinical Trial in Baltimore, MD

Access cutting-edge multiple sclerosis treatment through this phase 2 clinical trial at a research site in Baltimore. Study-provided care at no cost to qualified participants.

Sponsored by Johns Hopkins University

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Expert Care in Baltimore

Access multiple sclerosis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related multiple sclerosis treatment provided free

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Check if you qualify for this multiple sclerosis clinical trial in Baltimore, MD

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Why Participate?

  • No-Cost Study Care

  • Local to Baltimore

    Convenient for MD residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Baltimore site if eligible
  4. 4Begin participation

About This Multiple Sclerosis Study in Baltimore

Fatigue is a prevalent and disabling symptom in Multiple Sclerosis (MS), affecting up to 90% of patients. Current treatments, including off-label prescriptions of wake-promoting agents, have shown limited effectiveness. Previous research indicates that these agents may be beneficial specifically for MS patients with concomitant excessive daytime sleepiness. This study uses a randomized, double-blind, placebo-controlled crossover design. Participants will undergo a 10-day lead-in with he medication/placebo, followed by two four-week treatment periods separated by a one-week washout. Outcomes will be measured primarily using the Modified Fatigue Impact Scale (MFIS), with additional exploratory measures collected via a smartphone app that assesses fatigue through keystroke dynamics. This novel approach to fatigue measurement aims to capture real-time variations and provide more granular data than traditional self-report questionnaires.

Sponsor: Johns Hopkins University

Who Can Participate

Inclusion Criteria

Male or female, 18 to 60 years of age, inclusive.
Medically stable on the basis of physical examination, medical history, and vital signs
Must meet McDonald 2024 diagnostic criteria for multiple sclerosis based on the PI review of the medical records
Must complain from fatigue as one of their main symptoms and have a screening MFIS score of 33 or more
A screening ESS score of 10 or more
Must be ambulatory (able to walk at least 20 feet using bilateral assistance)
Must have internet and email access and the ability to use a computer or tablet, or smartphone
Own an android smartphone or an iphone
Consent to use a medically acceptable method of contraception for the duration of the study
Willing and able to comply with the study design schedule and other requirements
Willing and able to provide written informed consent

Exclusion Criteria

History of coronary artery disease or congestive heart failure
Uncontrolled hypertension at Screening (history of high blood pressure and screening systolic blood pressure \>160 or diastolic blood pressure\>100)
A known history of uncontrolled diabetes (the last known hemoglobin A1c level above 7.0%), high BMI (\>35), or hyperlipidemia (last known total cholesterol \>240 mg/dl, or LDL cholesterol level \>160 mg/dl)
Receiving drugs/treatments that increase blood pressure or heart rate (based on the PI review of the medications/treatments)
A history of cerebrovascular disease or stroke
A medical or neurological disorder other than MS, that was associated with excessive sleepiness.
A history of phenylketonuria or hypersensitivity to the phenylalanine-derived product
A history of alcohol or drug abuse within the past two years
A history of psychosis, or bipolar disorder
A history of cardiac arrythmias
The use of any product with stimulating or sedating properties, unless they have been on a steady dose for at least a month prior to the screening visit and agree to stay on the same dose over the course of the study
Use within 14 days of a monoamine oxidase (MAO) inhibitor drug
Pregnant or lactating
Use of medications used for the treatment of fatigue (including amantadine, modafinil, armodafinil, and amphetamine-like stimulants) in the past two weeks of the screening visit
A known history of moderate or severe kidney dysfunction (estimated Glomerular filtration rate of less than 60 mL/min)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Baltimore?

Yes, this clinical trial (NCT06170970) has an active research site in Baltimore, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Multiple Sclerosis Treatment Options in Baltimore, MD

If you're searching for multiple sclerosis treatment options in Baltimore, MD, this clinical trial (NCT06170970) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Baltimore research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced multiple sclerosis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all multiple sclerosis clinical trials near you to find additional studies recruiting in your area.

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