Is NCT06455969 recruiting in Pittsburgh, PA?

Yes, NCT06455969 is currently recruiting participants at its Pittsburgh, PA location. This musculoskeletal injury clinical trial is actively enrolling qualified participants.

How do I join the musculoskeletal injury clinical trial in Pittsburgh?

To join this clinical trial in Pittsburgh, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Pittsburgh clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Musculoskeletal Injury Clinical Trial in Pittsburgh, PA

About This Musculoskeletal Injury Study in Pittsburgh

Non-combat-related muscle, tendon and bone injuries are the most common injuries suffered by military personnel, particularly in new recruits. These injuries impact military readiness and are responsible for roughly 60% of limited duty days, 65% of soldiers who are unable to deploy, and nearly $500 million in medical cost to the government annually in the Army alone. Drug interventions must be studied and developed to prevent these negative outcomes and prepare military personnel for the demands of military service. At the current time, military leadership has identified critical gaps in understanding how to minimize these injuries and train soldiers with drug intervention serving among those gaps. The goal of this study is to determine how a hormonal intervention can change muscle, tendon, and bone function as well as physical and psychological performance in response to mental and physical stress. To do so, we will examine sex hormone (testosterone, estrogen) levels, muscle, tendon, and bone images, blood samples, and physical and mental performance. We will look at things like changes in hormone levels, chemicals released from active skeletal muscles, and your body composition. The results from this study will be used to improve physical readiness training in the military with the goal of reducing injuries.

Sponsor: Bradley Nindl

Who Can Participate

Inclusion Criteria

Age 18-40 years

body mass index (BMI) 18-30 kg/m2

weight stable (±10 lbs) in past 2 months

takes part in moderate physical activity for at least 150 minutes/week

currently free of upper or lower body /extremity injury or impairment

able to commit to study duration

agrees to adhere to study requirements

not taking prescription medications or be willing to refrain from medication prior to and throughout the study period, unless approved by study physician

in men, total testosterone concentration within normal physiological range (300-1000 ng/dL)

in women, eumenorrheic (cycles of 26-35 days) and not using hormonal contraceptives for previous 3 months

Exclusion Criteria

Current smoker

current clinical diagnosis of an eating disorder

use of medication incompatible with measurement of reproductive and metabolic hormones or which may interfere with any of the study outcomes

current oligo/amenorrhea in women

any metabolic or endocrine disease

has been diagnosed with a medical condition, physical or psychological, that currently prevents potential subjects from exercising

currently pregnant or becomes pregnant during the study

history of heart condition OR high blood pressure

treating physician requires subject participates in medically supervised physical activity only

history of drug addiction, or regular use of recreational drugs

currently undergoing treatment for or have a history of mental health conditions

irregular lab results (e.g., PSA \>3 ng/mL)

Current diagnoses of disorders known to affect bone metabolism including hyperthyroidism, hyperparathyroidism, osteomalacia, Cushing's, diabetes mellitus or renal insufficiency

Current use of medications known to affect bone metabolism including estrogens, androgens, anti-estrogens, bisphosphonates (oral bisphosphonates within one year of the baseline visit or IV bisphosphonates within three years of the baseline visit), calcitonin, fluoride, oral or inhaled glucocorticoids, suppressive doses of thyroxine, lithium, pharmacological doses of vitamin D (greater than 2000 IU/day), anti-convulsants, depot medroxyprogesterone within 6 months.

History of deep vein thrombosis, pulmonary embolism, or clotting disorders.

History of stroke or myocardial infarction

Serum 25-hydroxyvitamin D \< 20 ng/mL

Thyroid dysfunction

Serum creatinine \> 2 mg/dL

Personal history or history of a first-degree relative with breast cancer

Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \> 2x the upper limit of normal

Serum bilirubin \> 2 mg/dL

Serum alkaline phosphatase \> 150 U/L

Plasma hemoglobin \< 10 gm/dL

Hematocrit \> 50

Fracture within the last 6 months.

Serum testosterone level \< 270 or \> 1070 ng/dL

Systolic blood pressure \> 160 or diastolic blood pressure \> 95

Active substance abuse

Triglycerides \> 150 fasting

History of hereditary angioedema

History of chest pain at rest, during daily activities of living, or when performing physical activity

Musculoskeletal injury removing subject from physical activity for more than a month within the past 2 years

Recreational drug use more than 2 times per month in each of the previous 6 months

Self-reported vision is worse than 20/20.

Personal history or history of a first-degree relative with breast cancer

Experienced a fracture within the last 6 months

participated and taken investigational drug in any other clinical trial (including bioequivalence study) within six months prior to study drug administration

Diagnosed with eating disorder

Have food allergies, intolerance, restriction, or special diet needs

History of endometriosis

Current diagnosis of reproductive health issues, such as ovarian cysts, PCOS, pelvic lesions, undiagnosed ovarian enlargement

Have undiagnosed abnormal vaginal bleeding

Currently breastfeeding or within 2 months after stopping breastfeeding

Have dietary restrictions

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Pittsburgh?

Yes, this clinical trial (NCT06455969) has an active research site in Pittsburgh, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Musculoskeletal Injury Treatment Options in Pittsburgh, PA

If you're searching for musculoskeletal injury treatment options in Pittsburgh, PA, this clinical trial (NCT06455969) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Pittsburgh research site is actively enrolling participants for this clinical trial. You'll receive care from experienced musculoskeletal injury specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all musculoskeletal injury clinical trials near you to find additional studies recruiting in your area.

Musculoskeletal Injury Clinical Trial in Pittsburgh, PA

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