Boston, MANCT04833140Now EnrollingIRB Ready

NASH - Nonalcoholic Steatohepatitis Clinical Trial in Boston, MA

Access cutting-edge nash - nonalcoholic steatohepatitis treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related nash - nonalcoholic steatohepatitis treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This NASH - Nonalcoholic Steatohepatitis Study in Boston

Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States. Despite this, the treatment options remain limited. Preclinical and preliminary clinical data suggest that estrogen deficiency plays an important role in the pathology of steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Post-menopausal women are a growing population with particularly high risk of NASH due to their lack of estrogen. This study will examine the effect of estradiol on hepatic fibrosis and fat in post-menopausal women with NASH.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Postmenopausal women 45-70 years old
NASH by biopsy or NAFLD by imaging within 6 months of screen
Hepatitis C antibody and hepatitis B surface antigen negative
Negative mammogram within 1 year

Exclusion Criteria

Heavy alcohol use
Use of NASH pharmacotherapies within 12 months of study entry
Known cirrhosis, stage 4 fibrosis on biopsy, or clinical evidence of cirrhosis or portal hypertension on imaging or exam
Participation in NASH clinical trial within 6 months of study entry
Chronic use of corticosteroids, methotrexate, amiodarone, or tamoxifen within 6 months of entry
Known diagnosis of chronic liver disease other than NAFLD or found on biopsy
Contraindication to liver biopsy including INR \> 1.5, platelets \< 50,000/mL, ascites, chronic anticoagulation (other than aspirin), biliary obstruction, peritonitis, inability to lie supine for 30 minutes
Hgb \< 10.0 g/dL or glomerular filtration rate \< 60 mL/min
Contraindications to estrogen therapy
Any vaginal bleeding, including spotting, within the last year
Active malignancy
Severe chronic illness
Use of estrogen or progesterone within a year of baseline visit
Routine MRI exclusion criteria such as the presence of a pacemaker or cerebral aneurysm clip

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT04833140) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

NASH - Nonalcoholic Steatohepatitis Treatment Options in Boston, MA

If you're searching for nash - nonalcoholic steatohepatitis treatment options in Boston, MA, this clinical trial (NCT04833140) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced nash - nonalcoholic steatohepatitis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all nash - nonalcoholic steatohepatitis clinical trials near you to find additional studies recruiting in your area.

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