Beverly Hills, CANCT05401110Now EnrollingIRB Ready

Non Small Cell Lung Cancer Clinical Trial in Beverly Hills, CA

Access cutting-edge non small cell lung cancer treatment through this clinical trial at a research site in Beverly Hills. Study-provided care at no cost to qualified participants.

Sponsored by Karen Reckamp, MD, MS

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Expert Care in Beverly Hills

Access non small cell lung cancer specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related non small cell lung cancer treatment provided free

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Check if you qualify for this non small cell lung cancer clinical trial in Beverly Hills, CA

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Why Participate?

  • No-Cost Study Care

  • Local to Beverly Hills

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Beverly Hills site if eligible
  4. 4Begin participation

About This Non Small Cell Lung Cancer Study in Beverly Hills

The purpose of this study is to examine the combination of osimertinib and carotuximab to assess the safety and find the recommended dose for treatment of advanced EGFR-mutated non-small cell lung cancer (NSCLC). Safety and tolerability will be measured by the number of dose-limiting toxicities, according to National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) Version 5, to find the maximum tolerated dose. The secondary objectives include evaluating the rate of objective response rate, duration of response, progression-free survival, and disease control rate, along with assessing biomarkers through tumor tissue and circulating tumor DNA.

Sponsor: Karen Reckamp, MD, MS

Who Can Participate

Inclusion Criteria

Stage IV or recurrent/metastatic non-squamous NSCLC that harbors an EGFR activating mutation (Exon 21 L858R, Exon 19 deletion, Exon 18 G719X, Exon 21 L861Q, etc). Local testing for EGFR mutations is acceptable provided it was performed in a CLIA certified lab.
Part I: Progressive disease on at least one prior EGFR TKI
Part II, Cohort 1: Progressive disease on osimertinib or other prior EGFR TKIs
Part II, Cohort 2: Receiving osimertinib as front line treatment for less than 12 weeks. Persistent ctDNA with EGFR mutation between weeks 6-12 from the start of osimertinib treatment.
Age at least 18
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0-2
Archival tissue from a biopsy performed after progression of disease on previous EGFR TKI or willing to consent for a fresh tumor biopsy.
Measurable disease by RECIST 1.1.
Patients with untreated brain metastases are allowed provided that the patient is clinically asymptomatic and stable.
Patients must have completed prior chemotherapy ≥ 3 weeks or radiotherapy ≥ 2 weeks prior to receiving study drugs.
If the subject's most recent line of therapy is treatment with osimertinib, then all adverse events must be resolved to Grade 2 or better
If the subject's most recent line of therapy is any other treatment than osimertinib, then all Adverse Events must be resolved to grade 1 or better, with the exception of fatigue, alopecia and neuropathy (which must resolve to CTCAE grade 2).
Adequate organ function
Women of childbearing potential and men must agree to use adequate contraception while on study.
Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.

Exclusion Criteria

Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis requiring steroid treatment, or any evidence of clinically active interstitial lung disease.
Small cell lung cancer histology.
Other prior malignancy that might interfere with study endpoints per opinion of the investigator.
Prior exposure to carotuximab or any CD105 targeted antibody.
Any major surgical procedure within 2 weeks of starting therapy.
Patients must not have a history of uncontrolled or poorly-controlled hypertension defined as SBP \> 150 mmHg or DBP \> 90 mmHg within 28 days prior to enrollment.
Active bleeding or pathologic conditions that carries a high bleeding risk (e.g. gastric ulcers).
Use of thrombolytics within 10 days prior to the first day of carotuximab.
Known hypersensitivity to Chinese hamster ovary products or other recombinant human, chimeric, or humanized antibodies.
A known diagnosis of Osler-Weber-Rendu syndrome.
Ascites or pericardial or pleural effusion requiring external drainage procedures.
New evidence of leptomeningeal disease.
Acute cardiovascular event within the past 6 months.
Pregnancy or breastfeeding.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Beverly Hills?

Yes, this clinical trial (NCT05401110) has an active research site in Beverly Hills, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Non Small Cell Lung Cancer Treatment Options in Beverly Hills, CA

If you're searching for non small cell lung cancer treatment options in Beverly Hills, CA, this clinical trial (NCT05401110) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Beverly Hills research site is actively enrolling participants for this clinical trial. You'll receive care from experienced non small cell lung cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all non small cell lung cancer clinical trials near you to find additional studies recruiting in your area.

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