NCT06323954 · Georgia Institute of Technology
tVNS During Motor Training in Older Adults
What this study is about
The goal of this study is to learn about the effect of applying transcutaneous vagus nerve stimulation (tVNS) during motor training on motor learning in older adults. The main question it aims to answer is whether applying tVNS after successful motor trials (post-success tVNS) will facilitate the rate of motor learning.
View original scientific description
The goal of this study is to learn about the effect of applying transcutaneous vagus nerve stimulation (tVNS) during motor training on motor learning in older adults. The main question it aims to answer is whether applying tVNS after successful motor trials (post-success tVNS) will facilitate the rate of motor learning. Participants will be randomly assigned to tVNS or sham group and receive tVNS or sham, respectively, at the outer ear during finger control training sessions. Finger control performance will be tested before and after the training sessions without outer ear stimulation.
Interventions
PROCEDURE
tVNS stimulation
Electrical stimulation to the vagus nerve area.
PROCEDURE
Sham stimulation
Electrical stimulation to the non-vagus nerve area.
Primary outcome measures
Rate of error reduction
Time frame: 2 weeks
The slope of the reduction in the root mean square error of finger force
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 65-84 years old across all races, genders, and ethnicities.
- Right-handed
- Physically and cognitively healthy
Exclusion criteria
- Younger than 65 years old or older than 84 years old
- Current or history of cardiac disease
- Have an implanted device such as a neurostimulator or cochlear implant
- Current or history of tympanic membrane perforation
- Have a musculoskeletal issue that prevents hand function (e.g., arthritis)
- Have a vision problem not corrected by glasses or contact lenses
- Uncorrected auditory impairments
- Had a stroke or lesion (including tumor) in the brain
- Had a head injury or brain surgery
- Suffer from frequent or severe headaches
- Had a fainting spell or syncope
- Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work
- Have any implanted device such as cardiac pacemakers, medical pumps, or intracardiac lines
- Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer)
- Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor)
- Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion
- Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia)
- Suspected of pregnancy
- Cognitive status issues as confirmed with the Mini-Mental State Exam (MMSE \<26)
- Musculoskeletal condition or injury that would limit hand range of motion
Where
- Atlanta, Georgia
Collaborators
University of Florida
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 21, 2026 · Source of record for eligibility and locations