Access cutting-edge opioid consumption, postoperative treatment through this clinical trial at a research site in La Jolla. Study-provided care at no cost to qualified participants.
Quick Self-Assessment
See if you qualify for this La Jolla location
Preparing your pre-screening questions…
Access opioid consumption, postoperative specialists at no cost
This study follows strict safety protocols and ethical guidelines
All study-related opioid consumption, postoperative treatment provided free
Check if you qualify for this opioid consumption, postoperative clinical trial in La Jolla, CA
No-Cost Study Care
Local to La Jolla
Convenient for CA residents
Cutting-Edge Treatment
Access to innovative therapies
Expert Medical Care
Close monitoring by specialists
Possible Compensation*
For time and travel
*Compensation varies by study. Confirm details with coordinator.
The purpose of the study is to investigate the efficacy of suzetrigine for treatment of acute postoperative pain among surgical patients identified as high risk for persistent postoperative opioid use (POU). Using a validated artificial intelligence predictive model (termed SurgNet-POU) developed by the PI, electronic health record (EHR) data will be queried from all prospective surgical patients undergoing orthopedic surgery and inputted into the model to predict risk of POU (defined as requiring opioids ≥ 3 months after surgery). Those identified as high risk by the SurgNet-POU will be eligible candidates for this study. Suzetrigine (Vertex Pharmaceuticals) is an FDA-approved non-opioid oral analgesic that acts as a selective Nav1.8 sodium channel blocker. It has been shown to have efficacy in post-surgical pain and has compared favorably to placebo and similar to some opioids, without the risk of addiction or other adverse events related to opioids. Consented participants will be randomized to one of two arms: (1) standard care (termed standard care) defined as usual prescribing outpatient opioid analgesic protocols per surgical team; versus (2) standard care combined with 14-day regimen of suzetrigine. Those randomized to the suzetrigine arm will receive 100mg suzetrigine PO \~ 1-2 hours prior to surgery and take 50mg po twice a day for 14 days postoperatively. The primary outcome will be total opioid consumption over 14 days postoperatively. Secondary outcomes include average, highest and lowest pain scores at 7, 14, 30, and 90 days after surgery; and opioid consumption at 7, 30, and 90 days after surgery.
Sponsor: University of California, San Diego
Yes, this clinical trial (NCT07672015) has an active research site in La Jolla, CA that is currently enrolling participants.
Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.
Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.
Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.
If you're searching for opioid consumption, postoperative treatment options in La Jolla, CA, this clinical trial (NCT07672015) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.
Our La Jolla research site is actively enrolling participants for this clinical trial. You'll receive care from experienced opioid consumption, postoperative specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.
Looking for more options? Browse all opioid consumption, postoperative clinical trials near you to find additional studies recruiting in your area.
See all pulmonary embolism clinical trials recruiting in La Jolla — not just this study.
Browse Pulmonary Embolism Trials in La Jolla →