Coral Gables, FLNCT05451004Now EnrollingIRB Ready

Oropharyngeal Cancer Clinical Trial in Coral Gables, FL

Access cutting-edge oropharyngeal cancer treatment through this phase 3 clinical trial at a research site in Coral Gables. Study-provided care at no cost to qualified participants.

Sponsored by Canadian Cancer Trials Group

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Expert Care in Coral Gables

Access oropharyngeal cancer specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related oropharyngeal cancer treatment provided free

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Check if you qualify for this oropharyngeal cancer clinical trial in Coral Gables, FL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Coral Gables

    Convenient for FL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Coral Gables site if eligible
  4. 4Begin participation

About This Oropharyngeal Cancer Study in Coral Gables

This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?

Sponsor: Canadian Cancer Trials Group

Who Can Participate

Inclusion Criteria

Patients with pathologically proven diagnosis of lateralized OPC (tonsil, tongue base, soft palate, or pharyngeal wall) not involving or crossing midline.
HPV positive or negative (by p16 immunohistochemistry).
Clinical stage T1-3 M0 (UICC/AJCC TNM 8th Edition). Nodal involvement may include no nodes or single or multiple ipsilateral lymph nodes (largest ≤6cm in maximum diameter)
Radiological investigations within 8 weeks of registration:
CT or MRI of the neck (with head imaging as indicated);
PET-CT scan
Chest CT scan
Planned definitive RT or CRT with bilateral neck RT (patients planned for unilateral neck RT are excluded).
Intent to deliver concurrent chemotherapy or not must be known at the time of randomization. As this is a pragmatic trial, even patients who are not candidates for systemic therapy will be eligible for participation.
Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.
Willing to complete the quality of life and/or health utility questionnaire, if sufficiently fluent in available language(s).
Informed consent prior to registration
Accessible for treatment and follow-up.
Commencement of definitive RT within 28 days (+ 14 days) of randomization.
Injection procedure for lymphatic mapping may be performed in the nuclear medicine, ambulatory clinic, or operating room setting
Women/men of childbearing potential must have agreed to use a highly effective contraceptive method
Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
Patient must consent to provision of, and investigator(s) must confirm location and commitment to obtain a representation of formalin fixed paraffin block of non-cytology tumour tissue in order that the specific correlative marker assays

Exclusion Criteria

T1-T2 cancers isolated to the tonsil fossa (i.e. without any soft palate, tongue base, posterior pharyngeal wall or posterior tonsil pillar involvement) with no involved lymph nodes or with a single ipsilateral node \< 3 cm without extranodal extension.
Tonsil or tongue base primary cancer who have previously undergone diagnostic palatine or lingual tonsillectomy with either complete excision or with no clinically apparent residual disease
Previous head and neck cancer or multiple synchronous primary head and neck cancers
Previous induction or neo-adjuvant chemotherapy.
Previous radiation therapy to the head and neck or comprehensive neck dissection of at least 3 levels on either side (due to potential for disrupted lymphatic channels and drainage pathways). Patients who have had excisional biopsies of involved lymph nodes are eligible
Radiotracer allergy
Severe, active co-morbidity including any of the following:
Chronic Obstructive Pulmonary Disease or other pulmonary illness requiring hospitalization within 30 days of registration
Unstable angina and/or congestive heart failure requiring hospitalization within the 30 days of registration
Acute myocardial infarction within 30 days of study registration
Diseases precluding RT (e.g. scleroderma)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Coral Gables?

Yes, this clinical trial (NCT05451004) has an active research site in Coral Gables, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Oropharyngeal Cancer Treatment Options in Coral Gables, FL

If you're searching for oropharyngeal cancer treatment options in Coral Gables, FL, this clinical trial (NCT05451004) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Coral Gables research site is actively enrolling participants for this phase 3 clinical trial. You'll receive care from experienced oropharyngeal cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all oropharyngeal cancer clinical trials near you to find additional studies recruiting in your area.

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