Wilmington, DENCT02432625Now EnrollingIRB Ready

Osteogenesis Imperfecta Clinical Trial in Wilmington, DE

Access cutting-edge osteogenesis imperfecta treatment through this clinical trial at a research site in Wilmington. Study-provided care at no cost to qualified participants.

Sponsored by Baylor College of Medicine

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Expert Care in Wilmington

Access osteogenesis imperfecta specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related osteogenesis imperfecta treatment provided free

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Check if you qualify for this osteogenesis imperfecta clinical trial in Wilmington, DE

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Wilmington

    Convenient for DE residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Wilmington site if eligible
  4. 4Begin participation

About This Osteogenesis Imperfecta Study in Wilmington

Osteogenesis Imperfecta (OI) is a rare disorder of increased bone fragility characterized by fractures with minimal or absent trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss. It is seen in both genders and all races. The clinical features of OI represent a continuum varying from perinatal lethality to individuals with severe skeletal deformities, mobility impairments, and very short stature to nearly asymptomatic individuals with a mild predisposition to fractures, normal stature, and normal lifespan. Fractures can occur in any bone, but are most common in the extremities. These disorders can be devastating and progressive and result in deformity, chronic pain, impaired function and loss of quality of life. The overall goal of this study is to answer specific question about the natural history of brittle bone diseases as defined by molecular etiology and to develop the foundation for prospective clinical studies.

Sponsor: Baylor College of Medicine

Who Can Participate

Inclusion Criteria

Individuals with OI diagnosed by molecular (DNA) analysis OR
Individuals whose clinical history and radiographs are highly suggestive of OI, but whose diagnosis has not been verified by biochemical or molecular studies

Exclusion Criteria

Individuals who are unable to return for their scheduled follow up visits.
Individuals with skeletal dysplasias other than OI
Individuals with OI and a second genetic or syndromic diagnosis Vertebral Compression Fractures component Inclusion criteria • Patients with nonsense or frameshift mutations in COL1A1 or COL1A2 of any age and clinical features of OI type I. Exclusion criteria
Use of a bone-acting treatment agent such as bisphosphonates, calcitonin, calcitriol, fluoride, etc., within one year of enrollment.
Conditions other than Osteogenesis Imperfecta-HaploInsufficiency (OI-HI) affecting muscle and/or bone development (i.e. cerebral palsy, rickets)
Nonsense or frame shift mutations in the final coding exons of COL1A1 or COL1A2, as this may not lead to haploinsufficiency. Scoliosis in OI component: Inclusion Criteria
All study participants between the ages of 3 to 17 years OR
Study participants 18 years and older with scoliosis Dental and Craniofacial Abnormalities in OI component: Inclusion Criteria • All subjects aged 3 years and older enrolled in the Longitudinal Study Exclusion Criteria Subjects who refuse the dental examination Pregnancy in OI component: Inclusion criteria • Females of reproductive age with mutations in any known gene causing OI, who are contemplating pregnancy within 5 years of enrollment in the Natural History Study OR Females who are pregnant with available pre-pregnancy BMD (within 5 years prior to the first pregnancy visit). Exclusion criteria
Females who are peri-menopausal or menopausal
Females who had gestations associated with higher order multiples.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Wilmington?

Yes, this clinical trial (NCT02432625) has an active research site in Wilmington, DE that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Osteogenesis Imperfecta Treatment Options in Wilmington, DE

If you're searching for osteogenesis imperfecta treatment options in Wilmington, DE, this clinical trial (NCT02432625) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Wilmington research site is actively enrolling participants for this clinical trial. You'll receive care from experienced osteogenesis imperfecta specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all osteogenesis imperfecta clinical trials near you to find additional studies recruiting in your area.

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