Atlanta, GANCT05401630Now EnrollingIRB Ready

Post-menopause Clinical Trial in Atlanta, GA

Access cutting-edge post-menopause treatment through this clinical trial at a research site in Atlanta. Study-provided care at no cost to qualified participants.

Sponsored by Emory University

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Expert Care in Atlanta

Access post-menopause specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related post-menopause treatment provided free

Apply for This Atlanta Location

Check if you qualify for this post-menopause clinical trial in Atlanta, GA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Atlanta

    Convenient for GA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Atlanta site if eligible
  4. 4Begin participation

About This Post-menopause Study in Atlanta

Coronary Microvascular Dysfunction (CMD) occurs when there are problems in the small blood vessels/arteries of the heart, resulting in persistent chest pain that affects women. There are an estimated 3 million women in the US with CMD and about 100,000 new cases annually. This research will investigate whether the stress response physiology and autonomic function in response to mental stress are different in women with CMD compared to other groups. The autonomic nervous system (ANS) controls normally involuntary activities, such as heart rate, respiration (breathing), body temperature, blood pressure, and urinary function. This study will also examine how chronic and daily life mental stress affects the heart and blood vessels. Participants from this study will be recruited mainly from Emory Healthcare-associated hospitals, the Emory Heart Disease Center for Prevention, and Emory Healthcare outpatient cardiology clinics. Participants will have physical exams, blood tests, stress tests, exercise tests, surveys, questionnaires, and images taken of their hearts and blood vessels. They will be asked to take home devices to monitor their autonomic function, sleep, and track their mood, stress level, and symptoms for one week. Data and specimens will be saved for future research.

Sponsor: Emory University

Who Can Participate

Inclusion Criteria

Symptomatic postmenopausal women with chest pain
age≥45 years old
willing to undergo cardiac MIBG scan
willing to undergo mental stress testing
competent to give informed consent

Exclusion Criteria

Significant epicardial stenosis (defined by coronary stenosis ≥ 70% in any epicardial coronary artery or hemodynamically significant stenosis determined by fractional flow reserve)
Left ventricular systolic dysfunction (ejection fraction ≤ 50%)
Heart failure with a preserved ejection fraction
Significant anemia or blood dyscrasia
Severe uncontrolled hypertension \>180/100
Unable to lie flat for mental stress testing
Pre-menopausal
Pericarditis/myocarditis
History of percutaneous coronary intervention
Coronary artery bypass grafting
Acute myocardial infarction/acute coronary syndrome/unstable angina within 1 month
Significant valvular disease, including aortic or mitral stenosis
Sinus node dysfunction/pacemaker, 2nd or 3rd-degree atrioventricular block
Severe lung, renal, liver, or psychiatric illness
Current neoplasm
History of substance abuse
Acute illness such as infection in the previous 4 weeks
Life-expectancy less than 2 years
Unable to safely withdraw medications for mental stress testing
Significant psychiatric illness that precludes safe participation in the study
Conditions that preclude accurate or safe testing and patient refusal
Unable to consent Obstructive CAD (oCAD) Group Inclusion Criteria:
Symptomatic postmenopausal women with chest pain who have obstructive CAD in at least one epicardial coronary artery
willing to undergo cardiac MIBG scan
willing to undergo mental stress testing
competent to give informed consent Exclusion Criteria:
Significant epicardial stenosis (defined by coronary stenosis ≥ 70% in any epicardial coronary artery or hemodynamically significant stenosis determined by fractional flow reserve)
Left ventricular systolic dysfunction (ejection fraction ≤ 50%)
Heart failure with a preserved ejection fraction
Significant anemia or blood dyscrasia
Severe uncontrolled hypertension \>180/100
Unable to lie flat for mental stress testing
Pre-menopausal
Pericarditis/myocarditis
History of percutaneous coronary intervention
Coronary artery bypass grafting
Acute myocardial infarction/acute coronary syndrome/unstable angina within 1 month
Significant valvular disease, including aortic or mitral stenosis
Sinus node dysfunction/pacemaker, 2nd or 3rd-degree atrioventricular block
Severe lung, renal, liver, or psychiatric illness
Current neoplasm
History of substance abuse
Acute illness such as infection in the previous 4 weeks
Life expectancy is less than 2 years
Unable to safely withdraw medications for mental stress testing
Significant psychiatric illness that precludes safe participation in the study
Conditions that preclude accurate or safe testing and patient refusal
Unable to consent Asymptomatic Control Group Inclusion Criteria:
Asymptomatic postmenopausal women, age ≥ 45 years old
Healthy volunteer with no cardiac risk factors
No history or diagnosis of heart disease
Not on any cardiac medications
Normal maximal exercise treadmill stress testing (ETT)
Fully understanding and willing to undergo mental stress testing
Willing to sign the informed consent Exclusion Criteria:
Significant epicardial stenosis (defined by coronary stenosis ≥ 70% in any epicardial coronary artery or hemodynamically significant stenosis determined by fractional flow reserve)
Left ventricular systolic dysfunction (ejection fraction ≤ 50%)
Heart failure with a preserved ejection fraction
Significant anemia or blood dyscrasia
Severe uncontrolled hypertension \>180/100
Unable to lie flat for mental stress testing
Pre-menopausal
Pericarditis/myocarditis
History of percutaneous coronary intervention
Coronary artery bypass grafting
Acute myocardial infarction/acute coronary syndrome/unstable angina within 1 month
Significant valvular disease, including aortic or mitral stenosis
Sinus node dysfunction/pacemaker, 2nd or 3rd-degree atrioventricular block
Severe lung, renal, liver, or psychiatric illness
Current neoplasm
History of substance abuse
Acute illness such as infection in the previous 4 weeks
Life expectancy is less than 2 years
Unable to safely withdraw medications for mental stress testing
Significant psychiatric illness that precludes safe participation in the study
Orthopedic limitation that will prevent ETT
LDL \>120 mg/dL
Fasting blood glucose \>95 mg/dL
Hypertension, defined as resting BP \>120/80
Hyperlipidemia
Conditions that preclude accurate or safe testing and patient refusal
Unable to consent

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Atlanta?

Yes, this clinical trial (NCT05401630) has an active research site in Atlanta, GA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Post-menopause Treatment Options in Atlanta, GA

If you're searching for post-menopause treatment options in Atlanta, GA, this clinical trial (NCT05401630) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Atlanta research site is actively enrolling participants for this clinical trial. You'll receive care from experienced post-menopause specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all post-menopause clinical trials near you to find additional studies recruiting in your area.

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