NCT07222852 · Women and Infants Hospital of Rhode Island
Cardiovascular Protection After Preeclampsia With Enalapril
(CAPP-E)
What this study is about
The purpose of this study is to learn if postpartum women are willing to be randomly assigned to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.
View original scientific description
The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.
Interventions
DRUG
Enalapril
First-line anti-hypertensive treatment with enalapril
OTHER
Standard treatment
First-line anti-hypertensive treatment per standard of care
Primary outcome measures
Feasibility of enrollment
Time frame: 4 months
Proportion of approached individuals who are enrolled
Feasibility of retention
Time frame: 4 months
Retention of participants to 4 months postpartum
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Postpartum individuals
- ≥18 years old
- Hypertensive disorder of pregnancy
- Enrolled in Women and Infants Hospital Hypertension Equity remote monitoring program.
Exclusion criteria
- Maternal cardiac disease
- Individuals with pre-pregnancy hypertension or diabetes
- Allergy or contraindication to enalapril
Where
- Providence, Rhode Island
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 6, 2026 · Source of record for eligibility and locations