Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertens...
Oxytocin and Fetal Heart Rate Changes
The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxia...
Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide
Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension....
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
The purpose of this study is to assess the effectiveness of nipocalimab when compared to placebo in decreasing the risk of fetal anemia (a condition in which a baby's red blood cell volume falls below...
Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age
A randomized, controlled, non-placebo trial to primarily assess the effect of oral, outpatient antibiotics (i.e., azithromycin and amoxicillin) on latency (i.e., proportion of patients that deliver wi...
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithro...
Top Cities for Preeclampsia Clinical Trials
Preeclampsia clinical trials are recruiting across 22 cities. Here are the cities with the most active studies:
About Preeclampsia
Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of damage to organs, most often the liver and kidneys. It usually develops after 20 weeks of pregnancy and can be life-threatening. Treatment may include early delivery, blood pressure medications, and close monitoring.
Clinical trials are advancing new treatments for preeclampsia. Currently, 6 studies are recruiting a combined 12,348 participants across the United States. Research is being conducted by 5 organizations including Ohio State University, Unyime Ituk, The University of Texas Medical Branch, Galveston and 2 others.
2026 Preeclampsia Research Landscape
As of March 2026, the preeclampsia clinical trial landscape includes 6 actively recruiting studies across 22 cities in the United States. These studies are collectively seeking 12,348 participants, with an average enrollment target of 2,058 per study.
Research is being led by 5 different organizations, including Ohio State University, Unyime Ituk, The University of Texas Medical Branch, Galveston, Janssen Research & Development, LLC, University Hospitals Cleveland Medical Center.
Geographically, preeclampsia trials are most concentrated in Cleveland, Ohio (3 trials); Los Angeles, California (2 trials); New York, New York (2 trials); Chapel Hill, North Carolina (2 trials); Columbus, Ohio (2 trials) and 7 other cities.
Featured Preeclampsia Studies
Highlighted recruiting studies for preeclampsia, selected by enrollment size and research scope.
Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy (HDP), and that there are multiple factors associated with adherence with aspirin therapy that will be important to identify to enable optimal implementation of study findin...
Oxytocin and Fetal Heart Rate Changes
The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fet...
Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide
Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.
Frequently Asked Questions About Preeclampsia Clinical Trials
Are there preeclampsia clinical trials near me?
Yes, there are 6 preeclampsia clinical trials currently recruiting across 22+ cities in the United States, including Cleveland, Ohio; Los Angeles, California; New York, New York. Browse the studies above to find one at a location convenient for you.
How do I join a preeclampsia clinical trial?
To join a preeclampsia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are preeclampsia clinical trials free?
Yes, participation in preeclampsia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of preeclampsia treatments are being studied?
Current preeclampsia clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 5 research organizations.
Is it safe to participate in preeclampsia clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov