DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 ind...
Glycemic Control After Antenatal Corticosteroids in Women with Pregestational and Gestational Diabetes
There is a fundamental gap in understanding the maternal and neonatal effects of antenatal corticosteroid (ACS) administration in women with threatened preterm birth (PTB) who have diabetes. Since the...
Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational Diabetes
Pregnant women aged 18-40 with gestational diabetes (GDM) will take part in this study. We want to see how two different insulin treatments affect their blood sugar after they eat. These women usually...
Top Cities for Gestational Diabetes Clinical Trials
Gestational Diabetes clinical trials are recruiting across 15 cities. Here are the cities with the most active studies:
About Gestational Diabetes
Gestational diabetes develops during pregnancy when the body cannot make enough insulin to meet the extra needs. It can increase risks for both mother and baby if not managed. Treatment includes blood sugar monitoring, dietary changes, exercise, and sometimes insulin.
Clinical trials are advancing new treatments for gestational diabetes. Currently, 3 studies are recruiting a combined 1,722 participants across the United States. Research is being conducted by 3 organizations including Ohio State University, University of Alabama at Birmingham, Jaeb Center for Health Research.
2026 Gestational Diabetes Research Landscape
As of March 2026, the gestational diabetes clinical trial landscape includes 3 actively recruiting studies across 15 cities in the United States. These studies are collectively seeking 1,722 participants, with an average enrollment target of 574 per study.
Research is being led by 3 different organizations, including Ohio State University, University of Alabama at Birmingham, Jaeb Center for Health Research.
Geographically, gestational diabetes trials are most concentrated in Boston, Massachusetts (3 trials); New York, New York (2 trials); Portland, Oregon (2 trials); Tuscaloosa, Alabama (1 trial); Los Angeles, California (1 trial) and 7 other cities.
Featured Gestational Diabetes Studies
Highlighted recruiting studies for gestational diabetes, selected by enrollment size and research scope.
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) randomized to oral metformin versus injectable insulin. This study will determine if metformin is not inferior to insulin in reducing adverse pregnan...
Glycemic Control After Antenatal Corticosteroids in Women with Pregestational and Gestational Diabetes
There is a fundamental gap in understanding the maternal and neonatal effects of antenatal corticosteroid (ACS) administration in women with threatened preterm birth (PTB) who have diabetes. Since the initial discovery of ACS for neonatal benefit in 1972, more than 40 randomized controlled trials have been performed evaluating its efficacy. However, none of these trials have included women with T2...
Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational Diabetes
Pregnant women aged 18-40 with gestational diabetes (GDM) will take part in this study. We want to see how two different insulin treatments affect their blood sugar after they eat. These women usually use a rapid-acting insulin analog (RAA) that's injected to control their blood sugar before and after meals. They will come to the clinic for two meal sessions. For the first meal, we will randomly d...
Frequently Asked Questions About Gestational Diabetes Clinical Trials
Are there gestational diabetes clinical trials near me?
Yes, there are 3 gestational diabetes clinical trials currently recruiting across 15+ cities in the United States, including Boston, Massachusetts; New York, New York; Portland, Oregon. Browse the studies above to find one at a location convenient for you.
How do I join a gestational diabetes clinical trial?
To join a gestational diabetes clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are gestational diabetes clinical trials free?
Yes, participation in gestational diabetes clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of gestational diabetes treatments are being studied?
Current gestational diabetes clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 3 research organizations.
Is it safe to participate in gestational diabetes clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 2, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 2, 2026 · Data from ClinicalTrials.gov